Self-reported gastrointestinal adverse effects of non-steroidal anti-inflammatory drugs in female students with dysmenorrhoea at Makerere University: prevalence, discontinuation and associated factors. a cross sectional study.

Autor:	Gobba S; Makerere University, Kampala, Uganda solomongobba@gmail.com., Kibone W; Makerere University, Kampala, Uganda., Kiguba R; Pharmacology and Therapeutics, Makerere University College of Health Sciences, Kampala, Uganda.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2024 Jun 06; Vol. 14 (6), pp. e079660. Date of Electronic Publication: 2024 Jun 06.
DOI:	10.1136/bmjopen-2023-079660
Abstrakt:	Background: Primary dysmenorrhoea occurs in up to 50% of menstruating females. Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly used therapeutic remedies for dysmenorrhoea in Uganda. However, NSAIDs are associated with a 3-5 fold increase in the risk of gastrointestinal (GI) adverse drug effects. Objectives: We aimed to determine the prevalence and associated factors of self-reported NSAID-related GI adverse effects in female students who use NSAIDs in managing dysmenorrhoea-associated pain at Makerere University. Design: A cross-sectional study. Setting: Makerere University's main campus, situated North of Kampala, Uganda. Participants: 314 female students pursuing an undergraduate programme at Makerere University and residing in different halls of residence and hostels. Outcomes: Social demographic data, menstrual history and treatment data. Results: Overall, 314 valid responses were received from female students with a median age of 22 years (IQR: 18-29 years). The median age at menarche was 13 years (IQR: 9-18 years). 41% (n=129/314) of the respondents had used medication for dysmenorrhoea and 32% (n=41/129) of whom reported NSAID-associated GI adverse effects with nausea being the most frequently reported (44%, n=18/41)Factors independently associated with GI adverse effects were: age at menarche (p=0.026), duration of menstruation (p=0.030) and use of ibuprofen (p=0.005). Females taking ibuprofen for dysmenorrhoea were about four times as likely to have NSAID-associated GI adverse effects (adjusted OR 3.87, 95% CI 1.51 to 9.91) than those who did not receive ibuprofen. Logistic regression was used to determine factors associated with self-reported adverse effects of NSAIDs among the female students. A p<0.05 was considered statistically significant. Conclusion: We found a considerably high prevalence of NSAID-related GI adverse effects driven by factors such as age at menarche and ibuprofen use. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.)
Databáze:	MEDLINE
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