Cerebral Gray Matter May Not Explain Sleep Slow-Wave Characteristics after Severe Brain Injury.

Autor:	Kalantari N; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de Montréal, Montreal, Quebec H4J 1C5, Canada.; Department of Psychology, Université de Montréal, Montreal, Quebec H2V 2S9, Canada., Daneault V; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de Montréal, Montreal, Quebec H4J 1C5, Canada.; Department of Psychology, Université de Montréal, Montreal, Quebec H2V 2S9, Canada., Blais H; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de Montréal, Montreal, Quebec H4J 1C5, Canada., André C; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de Montréal, Montreal, Quebec H4J 1C5, Canada.; Department of Psychology, Université de Montréal, Montreal, Quebec H2V 2S9, Canada., Sanchez E; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de Montréal, Montreal, Quebec H4J 1C5, Canada.; Cognitive Neurology Research Unit, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada., Lina JM; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de Montréal, Montreal, Quebec H4J 1C5, Canada.; Department of Electrical Engineering, École de Technologie Supérieure, Montreal, Quebec H3C 1K3, Canada., Arbour C; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de Montréal, Montreal, Quebec H4J 1C5, Canada.; Faculty of Nursing, Université de Montréal, Montreal, Quebec H3T 1A8, Canada., Gilbert D; Department of Radiology, Radiation Oncology and Nuclear Medicine, Université de Montréal, Montreal, Quebec H3T 1A4, Canada.; Department of Radiology, Hôpital du Sacré-Coeur de Montréal, Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de Montréal, Montreal, Quebec H4J 1C5, Canada., Carrier J; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de Montréal, Montreal, Quebec H4J 1C5, Canada.; Department of Psychology, Université de Montréal, Montreal, Quebec H2V 2S9, Canada., Gosselin N; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de Montréal, Montreal, Quebec H4J 1C5, Canada nadia.gosselin@umontreal.ca.; Department of Psychology, Université de Montréal, Montreal, Quebec H2V 2S9, Canada.
Jazyk:	angličtina
Zdroj:	The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2024 Aug 07; Vol. 44 (32). Date of Electronic Publication: 2024 Aug 07.
DOI:	10.1523/JNEUROSCI.1306-23.2024
Abstrakt:	Sleep slow waves are the hallmark of deeper non-rapid eye movement sleep. It is generally assumed that gray matter properties predict slow-wave density, morphology, and spectral power in healthy adults. Here, we tested the association between gray matter volume (GMV) and slow-wave characteristics in 27 patients with moderate-to-severe traumatic brain injury (TBI, 32.0 ± 12.2 years old, eight women) and compared that with 32 healthy controls (29.2 ± 11.5 years old, nine women). Participants underwent overnight polysomnography and cerebral MRI with a 3 Tesla scanner. A whole-brain voxel-wise analysis was performed to compare GMV between groups. Slow-wave density, morphology, and spectral power (0.4-6 Hz) were computed, and GMV was extracted from the thalamus, cingulate, insula, precuneus, and orbitofrontal cortex to test the relationship between slow waves and gray matter in regions implicated in the generation and/or propagation of slow waves. Compared with controls, TBI patients had significantly lower frontal and temporal GMV and exhibited a subtle decrease in slow-wave frequency. Moreover, higher GMV in the orbitofrontal cortex, insula, cingulate cortex, and precuneus was associated with higher slow-wave frequency and slope, but only in healthy controls. Higher orbitofrontal GMV was also associated with higher slow-wave density in healthy participants. While we observed the expected associations between GMV and slow-wave characteristics in healthy controls, no such associations were observed in the TBI group despite lower GMV. This finding challenges the presumed role of GMV in slow-wave generation and morphology. Competing Interests: The authors declare no competing financial interests. (Copyright © 2024 the authors.)
Databáze:	MEDLINE
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