A hemodynamic study of the relationship between the left and right liver volumes and the blood flow distribution in portal vein branches.
| Autor: | Xie C; University of Science and Technology Beijing, Beijing, China., Sun S; University of Science and Technology Beijing, Beijing, China., Huang H; Liver Transplantation Section, Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China., Li X; University of Science and Technology Beijing, Beijing, China., Qu W; Liver Transplantation Section, Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China., Song H; University of Science and Technology Beijing, Beijing, China. |
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| Jazyk: | angličtina |
| Zdroj: | Medical physics [Med Phys] 2024 Sep; Vol. 51 (9), pp. 6501-6512. Date of Electronic Publication: 2024 Jun 06. |
| DOI: | 10.1002/mp.17184 |
| Abstrakt: | Background: Cirrhosis patients often exhibit clinical symptoms such as right liver atrophy, portal hypertension, spleen enlargement and increased blood supply, which exhibit considerable variation between the left and right liver sections. These differences are hypothesized to stem from disparities in blood flow within the left and right portal vein (PV) branches. However, rigorous quantitative evidence remains scarce. Purpose: We mainly aim at quantitatively revealing the relationship between the blood flow rates of two PV branches and liver volumes, and providing quantitative evidence and theoretical support for the diagnosis and treatment of cirrhosis from the perspective of hemodynamics. Methods: Five cirrhotic patients and two healthy volunteers from Beijing Friendship Hospital are investigated. Their PV blood flow models are established based on computed tomography (CT) images and finite volume simulations. The volume of the left and right liver lobes are measured in 3-matic. The distributions of blood source in the PV branches are tracked by streamline analysis. The blood flow rates are quantitatively counted by integrating the blood source velocities. Linear analysis is performed to build the relationship between liver volumes and PV blood flow distributions. Results: Streamline analysis reveals significant differences in blood distribution between the left and right PV branches. The majority of blood from the superior mesenteric vein (SMV) flowed into the right portal vein (RPV), while most blood from the splenic vein (SV) entered the left portal vein (LPV). The main PV pressure drop linearly increases with the SV blood velocity for all PV structures of patients and healthy volunteers. The flow rate ratio Q Conclusion: The differences in the blood distributions are consistent with the clinicians' knowledge and validate our simulations. We demonstrated a linear increase in PV pressure with elevated SV blood velocity. Additionally, the volumes of the left and right hepatic lobes exhibited a positive correlation with blood flow rates in the corresponding PV branches. (© 2024 American Association of Physicists in Medicine.) |
| Databáze: | MEDLINE |
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