Persistent spatial clustering and predictors of pediatric La Crosse virus neuroinvasive disease risk in eastern Tennessee and western North Carolina, 2003-2020.

Autor: Day CA; Entomology and Plant Pathology, University of Tennessee, Knoxville, Tennessee, United States of America., Odoi AO; Department of Biomedical and Diagnostic Sciences, University of Tennessee, Knoxville, Tennessee, United States of America., Moncayo A; Tennessee Department of Health, Nashville, Tennessee, United States of America., Doyle MS; North Carolina Division of Public Health, Raleigh, North Carolina, United States of America., Williams CJ; North Carolina Division of Public Health, Raleigh, North Carolina, United States of America., Byrd BD; Environmental Health Sciences, Western Carolina University, Cullowhee, North Carolina, United States of America., Trout Fryxell RT; Entomology and Plant Pathology, University of Tennessee, Knoxville, Tennessee, United States of America.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2024 Jun 06; Vol. 18 (6), pp. e0012186. Date of Electronic Publication: 2024 Jun 06 (Print Publication: 2024).
DOI: 10.1371/journal.pntd.0012186
Abstrakt: The combined region of eastern Tennessee and western North Carolina has a persistently high risk of pediatric La Crosse virus neuroinvasive disease (LACV-ND). To guide public health intervention in this region, the objectives of this retrospective ecological study were to investigate the geographic clustering and predictors of pediatric LACV-ND risk at the ZIP code tabulation area (ZCTA) level. Data on pediatric cases of LACV-ND reported between 2003 and 2020 were obtained from Tennessee Department of Health and North Carolina Department of Health and Human Services. Purely spatial and space-time scan statistics were used to identify ZCTA-level clusters of confirmed and probable pediatric LACV-ND cases from 2003-2020, and a combination of global and local (i.e., geographically weighted) negative binomial regression models were used to investigate potential predictors of disease risk from 2015-2020. The cluster investigation revealed spatially persistent high-risk and low-risk clusters of LACV-ND, with most cases consistently reported from a few high-risk clusters throughout the entire study period. Temperature and precipitation had positive but antagonistic associations with disease risk from 2015-2020, but the strength of those relationships varied substantially across the study area. Because LACV-ND risk clustering in this region is focally persistent, retroactive case surveillance can be used to guide the implementation of targeted public health intervention to reduce the disease burden in high-risk areas. Additional research on the role of climate in LACV transmission is warranted to support the development of predictive transmission models to guide proactive public health interventions.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Day et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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