Mode and Characteristics of Arrhythmia Initiation in Idiopathic Ventricular Fibrillation: A THESIS Substudy.

Autor:	Belhassen B; Heart Institute, Hadassah Medical Center, Jerusalem, and Tel-Aviv University, Tel-Aviv, Israel. Electronic address: bblhass@gmail.com., Conte G; Division of Cardiology, Cardiocentro Ticino Institute Ente Ospedaliero Cantonale, Lugano, Switzerland., Steinberg C; Institut Universitaire de Cardiologie et Pneumologie de Québec, Laval University, Quebec, Canada., Whitaker J; Department of Cardiology, King's College London, School of Biomedical Engineering and Imaging Sciences, St Thomas's Hospital, London, United Kingdom., Khan HR; Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Western University, London, Ontario, Canada., Laredo M; Institut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, and Sorbonne Université, Paris, France., Doldi F; Department of Cardiology II (Electrophysiology), University Hospital Münster, Münster, Germany., Ho R; Division of Cardiology, Department of Medicine, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA., Tadros R; Cardiovascular Genetics Centre, Montreal Heart Institute and Faculty of Medicine, Université de Montreal, Montreal, Quebec, Canada., Dinov B; Department of Electrophysiology, Heart Center University Leipzig, Leipzig, Germany., Chorin E; Department of Cardiology, Tel Aviv Sourasky Medical Center and Tel Aviv University, Tel Aviv, Israel., Hansom S; University of Ottawa Heart Institute, Ottawa, Ontario, Canada., Waintraub X; Institut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, and Sorbonne Université, Paris, France., Eckardt L; Department of Cardiology II (Electrophysiology), University Hospital Münster, Münster, Germany., Jankelson L; Leon H. Charney Division of Cardiology, Department of Internal Medicine, NYU Langone Health, New York City, New York, USA., Peichl P; Department of Cardiology, IKEM, Prague, Czech Republic., Mellor G; Department of Cardiology, Papworth Hospital NHS Foundation Trust, Cambridge, UK., Sy RW; Department of Cardiology, Royal Prince Alfred Hospital, and Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia., Rattanawong P; Department of Cardiovascular Medicine, Mayo Clinic, Phoenix, Arizona, USA and Demoulas Center for Cardiac Arrhythmias, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Stojkovic S; University Clinic for Internal Medicine II, Department of Cardiology, Medical University of Vienna, Vienna, Austria., Garber L; Leon H. Charney Division of Cardiology, Department of Internal Medicine, NYU Langone Health, New York City, New York, USA., Suna G; Department of Cardiology, Papworth Hospital NHS Foundation Trust, Cambridge, UK., Kautzner J; Department of Cardiology, IKEM, Prague, Czech Republic., Chan KH; Department of Cardiology, Royal Prince Alfred Hospital, and Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia., Srivathsan K; Department of Cardiovascular Medicine, Mayo Clinic, Phoenix, Arizona, USA., Tedrow U; Cardiology Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Havranek S; Cardiocenter, 2nd Internal Clinic-Cardiology and Angiology, General Faculty Hospital, Charles University, Prague, Czech Republic., Murgatroyd F; Department of Cardiology, King's College Hospital, London, UK., Shauer A; Heart Institute, Hadassah Medical Center, Jerusalem, Israel., Winkel BG; Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Page SP; Leeds Teaching Hospitals NHS Trust, Leeds, UK., Milman A; Arrhythmia Institute, Cardiovascular Division, Shamir Medical Center, Be'er Ya'akov, Israel and Tel Aviv University, Tel Aviv, Israel., Lador A; Houston Methodist DeBakey Heart and Vascular Center and Research Institute, Houston, Texas, USA., Ayou R; Department of Cardiology, Electrophysiology, Skaraborgs Sjukhus, Skövde, Sweden., Sellal JM; Department of Cardiology, CHRU-Nancy, Université de Lorraine, Nancy, France., Chevalier P; Service de Rythmologie, Centre de Référence National des Troubles du Rythme Cardiaque d'Origine Héréditaire de Lyon, Hôpital Cardiologique Louis Pradel, Hospices Civils de Lyon, Université de Lyon, Lyon, France., García-Fernández FJ; Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario de Burgos, Burgos, Spain., Reichlin T; Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Shah D; Department of Cardiology, University Hospital, Geneva, Switzerland., Nazer B; Division of Cardiology, University of Washington, Seattle, Washington, USA., Bermudez-Jimenez F; Cardiology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain., Nagase S; Department of Advanced Arrhythmia and Translational Medical Science, National Cerebral and Cardiovascular Center, Suita, Japan., Morita H; Department of Cardiovascular Medicine and Therapeutics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan., Nam GB; Department of Cardiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea., Pappone C; Arrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato, Milan, Italy., Lambiase PD; Cardiac Electrophysiology, St Bartholomew's Hospital, London, United Kingdom., Strohmer B; Clinic II for Internal Medicine, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Salzburg, Austria., Stuehlinger M; Department of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria., Gandjbakhch E; Institut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, and Sorbonne Université, Paris, France., Schulze-Bahr E; Institute for Genetics of Heart Diseases, University Hospital Münster, Münster, Germany., Krahn AD; Center for Cardiovascular Innovation, Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada., Tovia-Brodie O; Jesselson Integrated Heart Center, Shaare Zedek Medical Center, Jerusalem, Israel.
Jazyk:	angličtina
Zdroj:	JACC. Clinical electrophysiology [JACC Clin Electrophysiol] 2024 Aug; Vol. 10 (8), pp. 1794-1809. Date of Electronic Publication: 2024 Jun 05.
DOI:	10.1016/j.jacep.2024.03.036
Abstrakt:	Background: There is limited information on the mode of arrhythmia initiation in idiopathic ventricular fibrillation (IVF). A non-pause-dependent mechanism has been suggested to be the rule. Objectives: The aim of this study was to assess the mode and characteristics of initiation of polymorphic ventricular tachycardia (PVT) in patients with short or long-coupled PVT/IVF included in THESIS (THerapy Efficacy in Short or long-coupled idiopathic ventricular fibrillation: an International Survey), a multicenter study involving 287 IVF patients treated with drugs or radiofrequency ablation. Methods: We reviewed the initiation of 410 episodes of ≥1 PVT triplet in 180 patients (58.3% females; age 39.6 ± 13.6 years) with IVF. The incidence of pause-dependency arrhythmia initiation (prolongation by >20 ms of the preceding cycle length) was assessed. Results: Most arrhythmias (n = 295; 72%) occurred during baseline supraventricular rhythm without ambient premature ventricular complexes (PVCs), whereas 106 (25.9%) occurred during baseline rhythm including PVCs. Nine (2.2%) arrhythmias occurred during atrial/ventricular pacing and were excluded from further analysis. Mode of PVT initiation was pause-dependent in 45 (15.6%) and 64 (60.4%) of instances in the first and second settings, respectively, for a total of 109 of 401 (27.2%). More than one type of pause-dependent and/or non-pause-dependent initiation (mean: 2.6) occurred in 94.4% of patients with ≥4 events. Coupling intervals of initiating PVCs were <350 ms, 350-500 ms, and >500 ms in 76.6%, 20.72%, and 2.7% of arrhythmia initiations, respectively. Conclusions: Pause-dependent initiation occurred in more than a quarter of arrhythmic episodes in IVF patients. PVCs having long (between 350 and 500 ms) and very long (>500 ms) coupling intervals were observed at the initiation of nearly a quarter of PVT episodes. Competing Interests: Funding Support and Author Disclosures The authors have reported that they have no relationships relevant to the contents of this paper to disclose. (Copyright © 2024 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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