Life-Threatening Arrhythmias in Patients With Takotsubo Syndrome: Insights Into Pathophysiology and Treatment Innovations.
Autor: | La Vecchia G; Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy; Operative Unit of Diagnostic Interventional Cardiology, Isola Tiberina-Gemelli Isola, Rome, Italy., Del Buono MG; Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy; Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Sanna T; Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy; Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Capecchi PL; Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Division of Internal Medicine, Electroimmunology Unit, University Hospital 'Le Scotte,' Siena, Italy., Lazzerini PE; Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Division of Internal Medicine, Electroimmunology Unit, University Hospital 'Le Scotte,' Siena, Italy., Golino M; Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA; Robert M. Berne Cardiovascular Research Center and Division of Cardiology, University of Virginia, Charlottesville, Virginia, USA., Kron J; Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA., Rodriguez-Miguelez P; Department of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, Virginia, USA; Division of Pulmonary and Critical Care, Virginia Commonwealth University, Richmond, Virginia, USA., Pelargonio G; Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy; Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Abbate A; Robert M. Berne Cardiovascular Research Center and Division of Cardiology, University of Virginia, Charlottesville, Virginia, USA. Electronic address: antonio.abbate@virginia.edu. |
---|---|
Jazyk: | angličtina |
Zdroj: | JACC. Clinical electrophysiology [JACC Clin Electrophysiol] 2024 Aug; Vol. 10 (8), pp. 1943-1952. Date of Electronic Publication: 2024 Jun 05. |
DOI: | 10.1016/j.jacep.2024.03.034 |
Abstrakt: | Takotsubo syndrome (TTS) is a reversible form of acute myocardial injury due to a neurocardiogenic mechanism associated with a relevant risk for life-threatening ventricular arrhythmias, occurring in up to 25% of all patients and including both ventricular arrhythmias (especially) in the context of QT prolongation and atrial tachy- or bradyarrhythmias. The pathogenetic mechanisms of TTS-related arrhythmic complications are not completely understood, and there are no randomized clinical trials addressing the pharmacologic and nonpharmacologic management in this specific setting. In this narrative review, the authors provide an overview of the pathogenesis and the therapeutic management of arrhythmic complications in patients with TTS, along with the future perspectives and the remaining knowledge gaps in this field. Competing Interests: Funding Support and Author Disclosures Dr Abbate has received consulting fees from Cardiol, Implicit Biosciences, Novo Nordisk, Kiniksa, Olatec, and Serpin Pharma. Dr Sanna is a consultant for Medtronic. Dr Lazzerini has received a grant from Roche Italia outside the submitted work. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. (Copyright © 2024 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
Externí odkaz: |