The physiological significance of plasma-accessible carbonic anhydrase in the respiratory systems of fishes.

Autor: Harter TS; Department of Biology, McMaster University, Hamilton, ON, L8S 4K1, Canada. hartert@mcmaster.ca., Dichiera AM; College of William and Mary, Virginia Institute of Marine Science, Gloucester Point, VA, 23062, USA., Esbaugh AJ; Marine Science Institute, University of Texas at Austin, Port Aransas, TX, 78373, USA.
Jazyk: angličtina
Zdroj: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology [J Comp Physiol B] 2024 Oct; Vol. 194 (5), pp. 717-737. Date of Electronic Publication: 2024 Jun 06.
DOI: 10.1007/s00360-024-01562-4
Abstrakt: Carbonic anhydrase (CA) activity is ubiquitously found in all vertebrate species, tissues and cellular compartments. Most species have plasma-accessible CA (paCA) isoforms at the respiratory surfaces, where the enzyme catalyzes the conversion of plasma bicarbonate to carbon dioxide (CO 2 ) that can be excreted by diffusion. A notable exception are the teleost fishes that appear to lack paCA at their gills. The present review: (i) recapitulates the significance of CA activity and distribution in vertebrates; (ii) summarizes the current evidence for the presence or absence of paCA at the gills of fishes, from the basal cyclostomes to the derived teleosts and extremophiles such as the Antarctic icefishes; (iii) explores the contribution of paCA to organismal CO 2 excretion in fishes; and (iv) the functional significance of its absence at the gills, for the specialized system of O 2 transport in most teleosts; (v) outlines the multiplicity and isoform distribution of membrane-associated CAs in fishes and methodologies to determine their plasma-accessible orientation; and (vi) sketches a tentative time line for the evolutionary dynamics of branchial paCA distribution in the major groups of fishes. Finally, this review highlights current gaps in the knowledge on branchial paCA function and provides recommendations for future work.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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