Immunoexpression Patterns of Adhesion Molecules (E-cadherin, β-catenin, CD56) and Cytokeratins (CK19, CK20, HMWCK, CAM5.2) During Hair Development in Human Fetuses Compared With Adults.

Autor:	Zorlu Ö; Department of Dermatology and Venereology, Tekirdağ Namık Kemal University Faculty of Medicine, Tekirdağ, Turkey., Karabağ S; Department of Pathology, Tekirdağ Namık Kemal University Faculty of Medicine, Tekirdağ, Turkey., Erdoğan KE; Department of Pathology, Çukurova University Faculty of Medicine, Adana, Turkey., Aksın M; Department of Pathology, Çukurova University Faculty of Medicine, Adana, Turkey; and., Üstün B; Department of Obstetrics and Gynecology, Tekirdağ Namık Kemal University Faculty of Medicine, Tekirdağ, Turkey.
Jazyk:	angličtina
Zdroj:	The American Journal of dermatopathology [Am J Dermatopathol] 2024 Sep 01; Vol. 46 (9), pp. 572-580. Date of Electronic Publication: 2024 Jun 06.
DOI:	10.1097/DAD.0000000000002741
Abstrakt:	Abstract: Abnormalities in the expression of cytokeratins or adhesion molecules have been associated with hair disorders. The expression patterns of these molecules in the hair follicles of developing human fetuses are not obvious. We aimed to investigate the expression patterns of some cytokeratins and adhesion molecules in the hair follicle of human fetuses and compared them with adults. Forty-eight fetuses of >16 gestational weeks and 22 adult cases with total excisions of benign nevi or cysts were enrolled. The skin samples were taken from both the scalp and back of the fetuses. The histopathologically normal skin areas were evaluated in adults. CK19, CK20, CAM5.2, high-molecular-weight cytokeratin, E-cadherin, β-catenin, and CD56 immunohistochemical stainings were performed. In the fetus group, the staining scores declined in the third trimester but elevated and reached the highest level in adults, except for CD56, which did not stain any adult samples. All stainings were mostly observed in the outer root sheath, except CD56 that stained the perifollicular dermal sheath only in fetuses. E-cadherin, β-catenin, and high-molecular-weight cytokeratin strongly and diffusely stained all adult samples. CAM5.2 and CK19 scores were correlated in fetuses (scalp scores: r s = 0.405, P = 0.004; back scores: r s = 0.422, P = 0.003) and adults (back scores: r s = 0.562, P = 0.046). CD56 negativity indicated the immune-privilege feature of adult hair follicles. As CK19, CAM5.2 may be used to find the regions of stem cells or transient amplifying cells. Competing Interests: The authors declare no conflicts of interest. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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