Historic dog Furs Unravel the Origin and Artificial Selection of Modern Nordic Lapphund and Elkhound dog Breeds.

Autor:	Wang SZ; Key Laboratory of Genetic Evolution & Animal Models, Yunnan Key Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.; Yunnan Animal Science and Veterinary Institute, Kunming, China., Yan Y; State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, China., Widlund M; Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory, Stockholm, Sweden., Qian CC; Key Laboratory of Genetic Evolution & Animal Models, Yunnan Key Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China., Zhang LL; Xingzhi College, Zhejiang Normal University, Jinhua, China., Zhang SJ; Key Laboratory of Genetic Evolution & Animal Models, Yunnan Key Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China., Li ZM; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China., Cao P; Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China., Dai QY; Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China., Feng XT; Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China., Liu F; Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China., Wang L; State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, China., Gao C; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China., Fu QM; Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China., Hytönen MK; Department of Medical and Clinical Genetics, Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.; Folkhälsan Research Center, Helsinki, Finland., Lohi H; Department of Medical and Clinical Genetics, Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.; Folkhälsan Research Center, Helsinki, Finland., Savolainen P; Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory, Stockholm, Sweden., Wang GD; Key Laboratory of Genetic Evolution & Animal Models, Yunnan Key Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China.
Jazyk:	angličtina
Zdroj:	Molecular biology and evolution [Mol Biol Evol] 2024 Jul 03; Vol. 41 (7).
DOI:	10.1093/molbev/msae108
Abstrakt:	The origins and extreme morphological evolution of the modern dog breeds are poorly studied because the founder populations are extinct. Here, we analyse eight 100 to 200 years old dog fur samples obtained from traditional North Swedish clothing, to explore the origin and artificial selection of the modern Nordic Lapphund and Elkhound dog breeds. Population genomic analysis confirmed the Lapphund and Elkhound breeds to originate from the local dog population, and showed a distinct decrease in genetic diversity in agreement with intense breeding. We identified eleven genes under positive selection during the breed development. In particular, the MSRB3 gene, associated with breed-related ear morphology, was selected in all Lapphund and Elkhound breeds, and functional assays showed that a SNP mutation in the 3'UTR region suppresses its expression through miRNA regulation. Our findings demonstrate analysis of near-modern dog artifacts as an effective tool for interpreting the origin and artificial selection of the modern dog breeds. (© The Author(s) 2024. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution.)
Databáze:	MEDLINE
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