Effect of vigorous-intensity physical activity on incident cognitive impairment in high-risk hypertension.

Autor: Kazibwe R; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Schaich CL; Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Muhammad AI; Department of Medicine, Section on Hospital Medicine, Wisconsin College of Medicine, Milwaukee, Wisconsin, USA., Epiu I; Prince of Wales Clinical School, University of New South Wales Sydney, Sydney, New South Wales, Australia., Namutebi JH; Wake Forest University, School of Graduate Studies, Winston-Salem, North Carolina, USA., Chevli PA; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Kazibwe J; Department of Cardiology, Sheffield Teaching Hospital, Sheffield, UK., Hughes T; Department of Medicine, Section on Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Rikhi RR; Department of Internal Medicine, Section on Gerontology and Geriatrics Medicine & Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Shapiro MD; Department of Internal Medicine, Section on Gerontology and Geriatrics Medicine & Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Yeboah J; Department of Internal Medicine, Section on Gerontology and Geriatrics Medicine & Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Jul; Vol. 20 (7), pp. 4602-4612. Date of Electronic Publication: 2024 Jun 06.
DOI: 10.1002/alz.13887
Abstrakt: Introduction: We investigated the effect vigorous physical activity (VPA) on the risk of incident mild cognitive impairment (MCI) and probable dementia among individuals with high-risk hypertension.
Methods: Baseline self-reported frequency of VPA was categorized into low VPA (<1 session/week), and high VPA (≥1 session/week). We used multivariate Cox regression analysis to examine the association of VPA categories with incident MCI and probable dementia events.
Results: Participants in the high VPA category, compared with low VPA, experienced lower events rates (per 1000 person-years) of MCI (13.9 vs 19.7), probable dementia (6.3 vs 9.0), and MCI/probable dementia (18.5 vs 25.8). In the multivariate Cox regression model, high VPA, compared with low VPA, was associated with lower risk of MCI, probable dementia, and MCI/probable dementia (HR [95% CI]: 0.81 [0.68-0.97], 0.80 [0.63-1.03], and 0.82 [0.70-0.96]), respectively.
Discussion: This study provides evidence that VPA may preserve cognitive function in high-risk patients with hypertension.
Highlights: Hypertension is associated with an increased risk of cognitive impairment Physical activity (PA) is associated with a lower risk of decline in cognition The effect of ≥1 sessions of vigorous-intensity PA (VPA) per week was assessed This analysis included SPRINT MIND trial participants with high-risk hypertension ≥1 VPA sessions/week was associated with lower risk of future cognitive impairment.
(© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
Externí odkaz: