Granulocytic neoplasm suggestive of primary myeloid sarcoma in 3 dogs.
Autor: | Ubiali A; University of Milan, Milano, Italy., Martini V; University of Milan, Milano, Italy., Comazzi S; University of Milan, Milano, Italy., Iussich S; University of Turin, Torino, Italy., Miniscalco B; University of Turin, Torino, Italy., Poggi A; University of Turin, Torino, Italy., Morello E; University of Turin, Torino, Italy., Roccabianca P; University of Milan, Milano, Italy., Rütgen B; University of Veterinary Medicine Vienna, Wien, Austria., Zamboni C; University of Milan, Milano, Italy., Riondato F; University of Turin, Torino, Italy. |
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Jazyk: | angličtina |
Zdroj: | Veterinary pathology [Vet Pathol] 2025 Jan; Vol. 62 (1), pp. 48-52. Date of Electronic Publication: 2024 Jun 06. |
DOI: | 10.1177/03009858241257897 |
Abstrakt: | Myeloid sarcoma (MS) is a solid tumor of granulocytic origin with extramedullary localization. This tumor is rare in humans and animals. The diagnostic approach is heterogeneous, and the definitive diagnosis may be difficult to achieve. Primary MS has never been described as a spontaneous neoplasm in companion dogs. Two purebred and 1 mixed-breed dogs, 6- to 11-year-old, developed round cell tumors in the mediastinum, lymph nodes (LNs) and tonsils, and LNs, respectively. Granulocytic origin and exclusion of lymphoid lineage were confirmed by flow cytometry, supported by immunohistochemistry or immunocytochemistry. Pivotal to the diagnosis were positive labeling for myeloid (CD11b, CD14) and hematopoietic precursors (CD34) markers, along with negative labeling for lymphoid markers. Blood and bone marrow infiltration were not detected at initial diagnosis, excluding acute myeloid leukemia. The behavior of these tumors was aggressive, resulting in poor clinical outcomes, even when chemotherapy was attempted. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
Databáze: | MEDLINE |
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