Respiratory Syncytial Virus-Associated Hospitalizations in Children <5 Years: 2016-2022.

Autor:	McMorrow ML; Coronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.; US Public Health Service, Rockville, Maryland., Moline HL; Coronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.; US Public Health Service, Rockville, Maryland., Toepfer AP; Coronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia., Halasa NB; Vanderbilt University Medical Center, Nashville, Tennessee., Schuster JE; Children's Mercy, Kansas City, Missouri., Staat MA; Division of Infectious Diseases, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Williams JV; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania., Klein EJ; Seattle Children's Hospital, Seattle, Washington., Weinberg GA; Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York., Clopper BR; Coronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia., Boom JA; Texas Children's Hospital and Department of Pediatrics, Baylor College of Medicine, Houston, Texas., Stewart LS; Vanderbilt University Medical Center, Nashville, Tennessee., Selvarangan R; Children's Mercy, Kansas City, Missouri., Schlaudecker EP; Division of Infectious Diseases, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Michaels MG; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania., Englund JA; Seattle Children's Hospital, Seattle, Washington., Albertin CS; Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York., Mahon BE; Coronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia., Hall AJ; Coronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia., Sahni LC; Texas Children's Hospital and Department of Pediatrics, Baylor College of Medicine, Houston, Texas., Curns AT; Coronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Jazyk:	angličtina
Zdroj:	Pediatrics [Pediatrics] 2024 Jul 01; Vol. 154 (1).
DOI:	10.1542/peds.2023-065623
Abstrakt:	Background: The coronavirus disease 2019 pandemic disrupted respiratory syncytial virus (RSV) seasonality resulting in early, atypical RSV seasons in 2021 and 2022, with an intense 2022 peak overwhelming many pediatric healthcare facilities. Methods: We conducted prospective surveillance for acute respiratory illness during 2016-2022 at 7 pediatric hospitals. We interviewed parents, reviewed medical records, and tested respiratory specimens for RSV and other respiratory viruses. We estimated annual RSV-associated hospitalization rates in children aged <5 years and compared hospitalization rates and characteristics of RSV-positive hospitalized children over 4 prepandemic seasons (2016-2020) to those hospitalized in 2021 or 2022. Results: There was no difference in median age or age distribution between prepandemic and 2021 seasons. Median age of children hospitalized with RSV was higher in 2022 (9.6 months vs 6.0 months, P < .001). RSV-associated hospitalization rates were higher in 2021 and 2022 than the prepandemic average across age groups. Comparing 2021 to 2022, RSV-associated hospitalization rates were similar among children <2 years of age; however, children aged 24 to 59 months had significantly higher rates of RSV-associated hospitalization in 2022 (rate ratio 1.68 [95% confidence interval 1.37-2.00]). More RSV-positive hospitalized children received supplemental oxygen and there were more respiratory virus codetections in 2022 than in prepandemic seasons (P < .001 and P = .003, respectively), but there was no difference in the proportion hypoxemic, mechanically ventilated, or admitted to intensive care. Conclusions: The atypical 2021 and 2022 RSV seasons resulted in higher hospitalization rates with similar disease severity to prepandemic seasons. (Copyright © 2024 by the American Academy of Pediatrics.)
Databáze:	MEDLINE
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