The dual effect of vagus nerve stimulation in pediatric patients with drug-resistant epilepsy: Is there more than seizure control?

Autor:	Ashraf Mahmoud M; Neurosurgery Department, Ain Shams University, Cairo, Egypt., El Rashidi O; Department of Pediatrics, Ain Shams University, Cairo, Egypt., Halim G; Neurosurgery Department, Ain Shams University, Cairo, Egypt., Amgad Elkholy M; Neurosurgery Department, Ain Shams University, Cairo, Egypt., Aglan O; Neurosurgery Department, Ain Shams University, Cairo, Egypt., Rahman El Sabbagh A; Neurosurgery Department, Ain Shams University, Cairo, Egypt., Kamel Basha A; Neurosurgery Department, Ain Shams University, Cairo, Egypt., Hamdi H; Neurosurgery Department, Tanta University, Tanta, Egypt., El Sayed AM; Neurosurgery Department, Ain Shams University, Cairo, Egypt., Amin Saleh D; Department of Pediatrics, Ain Shams University, Cairo, Egypt., Shatla RH; Department of Pediatrics, Ain Shams University, Cairo, Egypt., Abdel Ghany W; Neurosurgery Department, Ain Shams University, Cairo, Egypt.
Jazyk:	angličtina
Zdroj:	Epilepsy & behavior reports [Epilepsy Behav Rep] 2024 Feb 12; Vol. 27, pp. 100653. Date of Electronic Publication: 2024 Feb 12 (Print Publication: 2024).
DOI:	10.1016/j.ebr.2024.100653
Abstrakt:	This is a retrospective and comparative pilot study to investigate the role of vagus nerve stimulation (VNS) in improving cognitive functions in the pediatric age group with drug resistant epilepsy (DRE). It was conducted from January 2018 to February 2023. Children between the ages of 4 and 18 years were divided into two groups, the "VNS group" and the "best medical treatment (BMT) group". Follow up period was 12 months. Demographic, clinical, etiological and investigational data were recorded. Cognitive assessment using the Modified Mini-Mental State Examination for children (MMSE) was recorded at baseline and 12 months later for each group. 76.4 % of patients were classified as epilepsy secondary to cerebral palsy. 75 % of patients showed ≥ 50 % seizure frequency reduction among the VNS group as compared to 12.5 % in the BMT group. None of both groups achieved seizure freedom. At 12 months, both BMT and VNS groups showed statistically significantly improved overall cognitive score from baseline records (p = 0.027) and (p = 0.012), respectively, with a significantly higher improvement in VNS group. Also, statistical sub-analysis of cognitive subscales in cerebral palsy patients in both groups was conducted and revealed a significant improvement (p = 0.02) in the VNS group. We concluded that there is a potential role of VNS in improving cognitive functions which was shown by using a cost-effective screening tool. A significant effect was observed specially in cerebral palsy patients. This is very beneficial in limited-resources countries since VNS has good safety profile, high seizure control, and added value to cognitive functions. Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Mohamed Amgad Elsayed Elkholy reports administrative support was provided by Ain Shams University Faculty of Medicine. Mohamed Amgad Elsayed Elkholy reports a relationship with Ain Shams University Faculty of Medicine that includes: employment and non-financial support. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors.)
Databáze:	MEDLINE
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