Postmortem imaging reveals patterns of medial temporal lobe vulnerability to tau pathology in Alzheimer's disease.

Autor: Ravikumar S; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA. sadhana.ravikumar@gmail.com., Denning AE; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA., Lim S; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA., Chung E; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA., Sadeghpour N; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA., Ittyerah R; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA., Wisse LEM; Institute for Clinical Sciences Lund, Lund University, Lund, Sweden., Das SR; Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA., Xie L; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA., Robinson JL; Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA., Schuck T; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lee EB; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Detre JA; Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA., Tisdall MD; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA., Prabhakaran K; Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA., Mizsei G; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA., de Onzono Martin MMI; Human Neuroanatomy Laboratory, University of Castilla La Mancha, Albacete, Spain., Arroyo Jiménez MDM; Human Neuroanatomy Laboratory, University of Castilla La Mancha, Albacete, Spain., Mũnoz M; Human Neuroanatomy Laboratory, University of Castilla La Mancha, Albacete, Spain., Marcos Rabal MDP; Human Neuroanatomy Laboratory, University of Castilla La Mancha, Albacete, Spain., Cebada Sánchez S; Human Neuroanatomy Laboratory, University of Castilla La Mancha, Albacete, Spain., Delgado González JC; Human Neuroanatomy Laboratory, University of Castilla La Mancha, Albacete, Spain., de la Rosa Prieto C; Human Neuroanatomy Laboratory, University of Castilla La Mancha, Albacete, Spain., Irwin DJ; Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA., Wolk DA; Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA., Insausti R; Human Neuroanatomy Laboratory, University of Castilla La Mancha, Albacete, Spain., Yushkevich PA; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA. pauly2@pennmedicine.upenn.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Jun 05; Vol. 15 (1), pp. 4803. Date of Electronic Publication: 2024 Jun 05.
DOI: 10.1038/s41467-024-49205-0
Abstrakt: Our current understanding of the spread and neurodegenerative effects of tau neurofibrillary tangles (NFTs) within the medial temporal lobe (MTL) during the early stages of Alzheimer's Disease (AD) is limited by the presence of confounding non-AD pathologies and the two-dimensional (2-D) nature of conventional histology studies. Here, we combine ex vivo MRI and serial histological imaging from 25 human MTL specimens to present a detailed, 3-D characterization of quantitative NFT burden measures in the space of a high-resolution, ex vivo atlas with cytoarchitecturally-defined subregion labels, that can be used to inform future in vivo neuroimaging studies. Average maps show a clear anterior to poster gradient in NFT distribution and a precise, spatial pattern with highest levels of NFTs found not just within the transentorhinal region but also the cornu ammonis (CA1) subfield. Additionally, we identify granular MTL regions where measures of neurodegeneration are likely to be linked to NFTs specifically, and thus potentially more sensitive as early AD biomarkers.
(© 2024. The Author(s).)
Databáze: MEDLINE
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