Higher exposure to 1,3-butadiene is associated with more severe hearing loss.

Autor: Han SY; Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Republic of Korea., Lee SY; Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, 101 Daehak-Ro, Jongno-gu, Seoul, Republic of Korea.; Medical Research Center, Sensory Organ Research Institute, Seoul National University, Seoul, Republic of Korea., Suh MW; Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, 101 Daehak-Ro, Jongno-gu, Seoul, Republic of Korea.; Medical Research Center, Sensory Organ Research Institute, Seoul National University, Seoul, Republic of Korea., Lee JH; Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, 101 Daehak-Ro, Jongno-gu, Seoul, Republic of Korea.; Medical Research Center, Sensory Organ Research Institute, Seoul National University, Seoul, Republic of Korea., Park MK; Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, 101 Daehak-Ro, Jongno-gu, Seoul, Republic of Korea. entpmk@gmail.com.; Medical Research Center, Sensory Organ Research Institute, Seoul National University, Seoul, Republic of Korea. entpmk@gmail.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Jun 05; Vol. 14 (1), pp. 12899. Date of Electronic Publication: 2024 Jun 05.
DOI: 10.1038/s41598-024-63757-7
Abstrakt: While volatile organic compounds (VOCs) impair various organs, their influence on hearing loss (HL) has not been extensively researched. We aimed to identify the association between VOCs and HL or high-frequency hearing loss (HFHL). We extracted data on age, sex, pure tone audiometry, hypertension, occupational noise exposure, and creatinine-corrected urine VOC metabolite concentrations from the eighth Korea National Health and Nutrition Survey. Among the VOC metabolites, N-acetyl-S-(benzyl)-L-cysteine (BMA, P = 0.004), N-acetyl-S-(phenyl)-L-cysteine (SPMA, P = 0.027), and N-acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (DHBMA, P < 0.001) showed associations with HL. Additionally, HFHL exhibited significant associations with BMA (P = 0.005), 3- and 4-methylhippuric acid (3, 4 MHA, P = 0.049), mandelic acid (MA, P = 0.015), SPMA (P < 0.001), N-acetyl-S-(3-hydroxypropyl)-L-cysteine (3-HPMA, P < 0.001), and DHBMA (P < 0.001). After controlling other factors, DHBMA were associated with HL (P = 0.021) and HFHL (P = 0.014) and exhibited a linear association with the mean hearing level (β = 0.054, P = 0.024) and high-frequency hearing level (β = 0.045, P = 0.037). Since 1,3-butadiene may act as an ototoxic material, early screening for workers exposed to 1,3-butadiene and reducing exposure to 1,3-butadiene in everyday life may be helpful to prevent further HL.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: