Effectiveness of increasing the scalp cooling duration to prevent alopecia during adjuvant chemotherapy for breast cancer: a randomized pilot study.

Autor: Carton E; CHP Saint Grégoire, ICRB, Oncologie-Radiothérapie - boulevard de la Boutière, 35760, Saint Grégoire, France., Blas AM; CHP Saint Grégoire, ICRB, Oncologie-Radiothérapie - boulevard de la Boutière, 35760, Saint Grégoire, France., Perret C; CHP Saint Grégoire, ICRB, Oncologie-Radiothérapie - boulevard de la Boutière, 35760, Saint Grégoire, France., Le Bihan M; Direction des Soins Territoire Bretagne, Vivalto Santé, 9 boulevard de la Boutière, 35760, Saint Grégoire, France. mlebihan@vivalto-sante.com.
Jazyk: angličtina
Zdroj: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2024 Jun 05; Vol. 32 (7), pp. 410. Date of Electronic Publication: 2024 Jun 05.
DOI: 10.1007/s00520-024-08579-z
Abstrakt: Purpose: Alopecia is a common side-effect of chemotherapy and can be extremely distressing to patients. Scalp cooling can be used to reduce hair loss, but the optimal duration of cooling remains unclear. Our aim was to determine whether increasing the duration of scalp cooling improves hair preservation.
Methods: Patients with HER2-negative, non-metastatic, breast cancer received scalp cooling during adjuvant chemotherapy: three cycles of epirubicin/cyclophosphamide (EC) followed by three cycles of paclitaxel. The patients were randomly assigned to two groups. Group A (n=18) wore a Paxman cooling cap during each infusion and for 30 min post-infusion while Group B (n=19) wore the cap from 30 min before to 2 h after each infusion. All patients were asked to complete a questionnaire recording hair loss/regrowth, adverse events, and quality of life. Success of treatment was defined as <50% hair loss.
Results: The success rates after each of the three cycles did not differ significantly between the two groups (EC: Group A: 40%, Group B: 44%; paclitaxel: Group A: 50%, Group B: 36%; p>0.05). Hair regrowth was significantly higher in Group B at the 8-week follow-up, but not at the 6-month follow-up. Head discomfort affected more patients in Group B than in Group A during the first session (94% vs. 62%, respectively; p=0.039).
Conclusion: Long duration scalp cooling during chemotherapy might increase patients' discomfort and does not appear to improve hair preservation.
(© 2024. The Author(s).)
Databáze: MEDLINE
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