Fruits and vegetables intake and bladder cancer risk: a pooled analysis from 11 case-control studies in the BLadder cancer Epidemiology and Nutritional Determinants (BLEND) consortium.

Autor: Boot IWA; Department of Epidemiology, Maastricht University, P. Debeyeplein 1, 6229 HA, Maastricht, The Netherlands.; CAPHRI, Department of Epidemiology, Maastricht University Medical Centre+, Maastricht, The Netherlands.; School of Nutrition and Translational Research in Metabolism, Maastricht University, 6229 ER, Maastricht, The Netherlands., Wesselius A; Department of Epidemiology, Maastricht University, P. Debeyeplein 1, 6229 HA, Maastricht, The Netherlands. anke.wesselius@maastrichtuniversity.nl., Jochems SHJ; Department of Epidemiology, Maastricht University, P. Debeyeplein 1, 6229 HA, Maastricht, The Netherlands., Yu EYW; CAPHRI, Department of Epidemiology, Maastricht University Medical Centre+, Maastricht, The Netherlands.; School of Nutrition and Translational Research in Metabolism, Maastricht University, 6229 ER, Maastricht, The Netherlands.; Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing, 210009, China., Bosetti C; Unit of Cancer Epidemiology, Department of Oncology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Via Giuseppe La Masa 19, 20156, Milan, Italy., Taborelli M; Unit of Cancer Epidemiology, CRO Aviano National Cancer Institute, Aviano, PN, Italy., Porru S; Department of Diagnostics and Public Health, Section of Occupational Health, University of Verona, Verona, Italy.; Interuniversity Research Center, Integrated Models for Prevention and Protection in Environmental and Occupational Health, MISTRAL, University of Brescia, University of Milano-Bicocca, University of Verona, Verona, Italy., Carta A; Interuniversity Research Center, Integrated Models for Prevention and Protection in Environmental and Occupational Health, MISTRAL, University of Brescia, University of Milano-Bicocca, University of Verona, Verona, Italy., Golka K; Leibniz Research Centre for Working Environment and Human Factors, Sektion Lebenswissenschaften, Dortmund, Germany., Jiang X; Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.; Department of Ophthalmology, University of Southern California, Los Angeles, CA, USA., Stern MC; Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA., Kellen E; Leuven University Centre for Cancer Prevention (LUCK), Leuven, Belgium., Pohlabeln H; Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany., Tang L; Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA., Karagas MR; Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Zhang ZF; Departments of Epidemiology, UCLA Center for Environmental Genomics, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, CA, USA., Taylor JA; Epidemiology Branch, and Epigenetic and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA., La Vecchia C; Department of Clinical Medicine and Community Health, Università degli Studi di Milano, 20133, Milan, Italy., Zeegers MP; Department of Epidemiology, Maastricht University, P. Debeyeplein 1, 6229 HA, Maastricht, The Netherlands.
Jazyk: angličtina
Zdroj: European journal of nutrition [Eur J Nutr] 2024 Oct; Vol. 63 (7), pp. 2477-2498. Date of Electronic Publication: 2024 Jun 05.
DOI: 10.1007/s00394-024-03436-5
Abstrakt: Purpose: High consumption of fruits and vegetables decrease the risk of bladder cancer (BC). The evidence of specific fruits and vegetables and the BC risk is still limited.
Methods: Fruit and vegetable consumptions in relation to BC risk was examined by pooling individual participant data from case-control studies. Unconditional logistic regression was used to estimate study-specific odds ratio's (ORs) with 95% confidence intervals (CIs) and combined using a random-effects model for intakes of total fruits, total vegetables, and subgroups of fruits and vegetables.
Results: A total of 11 case-control studies were included, comprising 5637 BC cases and 10,504 controls. Overall, participants with the highest intakes versus the lowest intakes of fruits in total (OR 0.79; 95% CI 0.68-0.91), citrus fruits (OR 0.81; 95% CI 0.65-0.98), pome fruits (OR 0.76; 95% CI 0.65-0.87), and tropical fruits (OR 0.84; 95% CI 0.73-0.94) reduced the BC risk. Greater consumption of vegetables in total, and specifically shoot vegetables, was associated with decreased BC risk (OR 0.82; 95% CI 0.68-0.96 and OR 0.87; 95% CI 0.78-0.96, respectively). Substantial heterogeneity was observed for the associations between citrus fruits and total vegetables and BC risk.
Conclusion: This comprehensive study provides compelling evidence that the consumption of fruits overall, citrus fruits, pome fruits and tropical fruits reduce the BC risk. Besides, evidence was found for an inverse association between total vegetables and shoot vegetables intake.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: