Exosome Therapy for a Nonhealing Scalp Wound Following Chemoradiation and Surgical Therapy.

Autor:	Pumford AD; Alix School of Medicine, Mayo Clinic, Rochester, MN., Staricha KL; Department of Otolaryngology-Head & Neck Surgery, Mayo Clinic, Rochester, MN., Kunkel ET; Department of Otolaryngology-Head & Neck Surgery, Mayo Clinic, Rochester, MN., Armstrong MF; Department of Otolaryngology-Head & Neck Surgery, Mayo Clinic, Rochester, MN., Behfar A; Department of Cardiovascular Medicine, Van Cleve Cardiac Regenerative Medicine Program, Mayo Clinic, Rochester, MN., Van Abel KM; Department of Otolaryngology-Head & Neck Surgery, Mayo Clinic, Rochester, MN. Electronic address: vanabel.kathryn@mayo.edu.
Jazyk:	angličtina
Zdroj:	Mayo Clinic proceedings [Mayo Clin Proc] 2024 Jun; Vol. 99 (6), pp. 1006-1012.
DOI:	10.1016/j.mayocp.2024.04.011
Abstrakt:	This case report describes the safety and utility of a noninvasive therapy, Purified Exosome Product (PEP), for poorly healing scalp wounds in the setting of prior chemoradiation and surgery. A man in his 60s with a history of high-grade angiosarcoma of the right temporoparietal scalp reconstruction had a 1-year history of 2 nonhealing scalp wounds after neoadjuvant chemotherapy followed by concurrent chemoradiation therapy, wide local excision, and latissimus dorsi free flap and split-thickness skin graft. The patient underwent débridement followed by 4 collagen (Bellafill)-PEP and 4 fibrin (Tisseel)-PEP applications during 7 months in 2022. Photographs of the area of exposed bone of the temporoparietal wound were measured and standardized by ImageJ open-source software. The frontal wound was not routinely measured and therefore was qualitatively assessed by reviewing photographs over time. The frontal wound completely healed, and the temporoparietal wound showed a 96% decrease in overall size. The patient had no adverse effects of treatment and continues to demonstrate ongoing healing. This case exhibits the safety and utility of topical PEP therapy for noninvasive treatment of poorly healing scalp wounds and offers the potential for an alternative treatment of patients who are poor candidates for additional surgical intervention. (Copyright © 2024 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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