The HyperPed-COVID international registry: Impact of age of onset, disease presentation and geographical distribution on the final outcome of MIS-C.

Autor: Caorsi R; IRCCS Istituto Giannina Gaslini, UOC Reumatologia e Malattie Autoinfiammatorie, Genoa, Italy., Consolaro A; IRCCS Istituto Giannina Gaslini, UOC Reumatologia e Malattie Autoinfiammatorie, Genoa, Italy; Università Degli Studi di Genova, Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili (DiNOGMI), Genoa, Italy., Speziani C; IRCCS Istituto Giannina Gaslini, UOC Reumatologia e Malattie Autoinfiammatorie, Genoa, Italy., Sozeri B; Health Sciences University, Umraniye Training and Research Hospital, Department of Pediatric Rheumatology, Istanbul, Turkey., Ulu K; Health Sciences University, Umraniye Training and Research Hospital, Department of Pediatric Rheumatology, Istanbul, Turkey., Faugier-Fuentes E; Hospital Infantil de México Federico Gómez, Medicina Interna y Reumatologia, Mexico City, Mexico., Menchaca-Aguayo H; Hospital Infantil de México Federico Gómez, Medicina Interna y Reumatologia, Mexico City, Mexico., Ozen S; Hacettepe University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Rheumatology, Ankara, Turkey., Sener S; Hacettepe University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Rheumatology, Ankara, Turkey., Akhter Rahman S; Bangabandhu Sheikh Mujib Medical University (BSMMU), Paediatrics, Dhaka, Bangladesh., Imnul Islam M; Bangabandhu Sheikh Mujib Medical University (BSMMU), Paediatrics, Dhaka, Bangladesh., Haerynck F; Gent University Hospital, Pediatric Rheumatology, Gent, Belgium., Simonini G; IRCCS Meyer Children's Hospital, Rheumatology Unit, ERN-ReCONNECT Center, Florence, Italy., Mastri MV; Hospital Interzonal de Agudos Especializado en Pediatría, Sor María Ludovica. Sala de Reumatologia La Plata, Argentina., Avcin T; University Children's Hospital, University Medical Center Ljubljana, Department of Allergology, Rheumatology and Clinical Immunology, Ljubljana, Slovenia., Sršen S; University Hospital Centre Split, Department of Pediatrics, Split, Croatia., de Albuquerque Pedrosa Fernandes T; São Paulo State University (UNESP), Botucatu, Brazil., Stanevicha V; Riga Stradins University, Children University Hospital, Riga, Latvia., Vojinovic J; University of Nis, Faculty of Medicine, University Clinical Center Nis, Clinic of Pediatrics, Department of Pediatric Rheumatology, Nis, Serbia., Sobh A; Mansoura University Children's Hospital, Faculty of Medicine Mansoura University, Mansura, Egypt., Fingerhutova S; General University Hospital and 1st Faculty of Medicine, Charles University, Prague, Czech Republic., Minxova L; University Hospital Hradec Kralove, Department of Pediatrics, Hradec Kralove, Czech Republic., Gagro A; Children's Hospital Zagreb, Department of Pulmonology, Allergology, Clinical Immunology and Rheumatology, The University of Zagreb School of Medicine, Zagreb, Croatia., Rodrigues Fonseca A; Universidade Federal Do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Rio de Janeiro, Brazil., Pandya D; Amruta Hospital, Pediatrics, Rajkot, India., Varbanova B; Varna Medical University, Department of Pediatrics First Pediatric Clinic, Varna, Bulgaria., Sánchez-Manubens J; Hospital Parc Taulí de Sabadell, Reumatologia Pediàtrica - Servei de Medicina Pediàtrica, Barcelona, Spain., Ganeva M; University Children Hospital, Department of Paediatric Rheumatology, Sofia, Bulgaria., Montin D; Regina Margherita Children Hospital, Immunology and Rheumatology Unit, Turin, Italy., Boyarchuk O; I.Horbachevsky Ternopil National Medical University, Department of Children's Diseases and Pediatric Surgery, Ternopil, Ukraine., Minghini A; IRCCS Istituto Giannina Gaslini, UOC Reumatologia e Malattie Autoinfiammatorie, Genoa, Italy., Bracaglia C; IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy., Brogan P; UCL GOS Institute of Child Health, London, UK., Candotti F; Division of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Cattalini M; Pediatrics Clinic, University of Brescia and ASST Spedali Civili di Brescia, Brescia, Italy., Meyts I; UZ Leuven - Universitair Ziekenhuis, Leuven, Belgium., Minoia F; Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Pediatria e Immunoreumatologia2 Milan, Italy., Taddio A; Institute of Child and Maternal Health - IRCCS 'Burlo Garofolo' and University of Trieste, Trieste, Italy., Wouters C; UZ Leuven - Universitair Ziekenhuis, Leuven, Belgium; KU Leuven - University of Leuven, Department of Microbiology and Immunology, Laboratory Immunobiology, Leuven, Belgium., De Benedetti F; IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy., Bovis F; University of Genoa, Department of Health Sciences (DISSAL), Genoa, Italy., Ravelli A; IRCCS Istituto Giannina Gaslini, Direzione Scientifica, Genoa, Italy., Ruperto N; IRCCS Istituto Giannina Gaslini, UOC Servizio di Sperimentazioni Cliniche Pediatriche, PRINTO, Genoa, Italy., Gattorno M; IRCCS Istituto Giannina Gaslini, UOC Reumatologia e Malattie Autoinfiammatorie, Genoa, Italy. Electronic address: marcogattorno@gaslini.org., Bilginer Y; Hacettepe University Children's Hospital, Ankara, Turkey., Laila K; Bangabandhu Sheikh Mujib Medical Universit, Dhaka, Bangladesh., Islam MM; Bangabandhu Sheikh Mujib Medical Universit, Dhaka, Bangladesh., Meertens B; Gent University Hospital, Gent, Belgium., Hoste L; Gent University Hospital, Gent, Belgium., Dehoorne J; Gent University Hospital, Gent, Belgium., Schelstraete P; Gent University Hospital, Gent, Belgium., Vandekerckhove K; Gent University Hospital, Gent, Belgium., Willems J; Gent University Hospital, Gent, Belgium., Matthijs I; AZ Delta, Rumbeke, Belgium., Filocamo E Gisella Beatrice Beretta G; Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy., Magalhaes CS; Hospital Das Clínicas - Botucatu Medicine University, UNESP, Botucatu, Brazil., Chubata O; Ternopil Regional Children's Hospital, Ternopil, Ukraine., Ricci F; Clinica Pediatrica Dell'Università di Brescia, Spedali Civili, Brescia, Italy., Vukovic A; Universitiy Hospital Centre Split, Split, Croatia., Temelkova K; University Children Hospital, Sofia, Bulgaria., Avramovic MZ; Tajnsek University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia., Emersic N; Tajnsek University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia., Bizjak M; Tajnsek University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia., Vesel T; Tajnsek University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia., Rodrigues MF; Universidade Federal Do Rio de Janeiro, Rio de Janeiro, Brazil., Gasparello de Almeida R; Universidade Federal Do Rio de Janeiro, Rio de Janeiro, Brazil., Lukjanovica K; University Children Hospital, Riga, Latvia., Elnagdy MH; Mansoura University Faculty of Medicine, Mansoura, Egypt., Soliman A; Mansoura University, Mansoura, Egypt., Terifajova E; University Hospital Hradec Kralove, Hradec Kralove, Czech Republic., Brejchova I; České Budějovice Hospital, Ceske Budejovice, Czech Republic., Magner M; Thomayer University Hospital, Prague, Czech Republic., Myrup C; Rigshospitalet, Copenhagen, Denmark., Vougiouka O; P a A Kyriakou Children's Hospital, Athens, Greece., Jelusic M; University Hospital Centre Zagreb, University School of Medicine, Zagreb, Croatia., La Torre F; Ospedale Pediatrico Giovanni XXIII - Azienda Ospedaliero-Universitaria Consorziale-Policlinico, Bari, Italy., Rigante D; Cattolica Sacro Cuore University, Roma, Italy., Maggio MC; Children Hospital 'G. Di Cristina', Palermo, Italy., Verdoni L; ASST Papa Giovanni XXIII, Bergamo, Italy., Rubio-Perez N; Hospital Universitario Dr. J. E. Gonzalez, Universidad, Autónoma de Nuevo León, Monterrey, NL, Mexico., Cornejo GV; Hospital México Americano, Guadalajara, Mexico., Villarreal Trevino AV; Hospital Universitario Dr. J. E. Gonzalez, Universidad, Autónoma de Nuevo León, Monterrey, NL, Mexico., Brito I; Hospital Sao Joao, Porto, Portugal., Oliveira-Ramos F; Hospital Santa Maria, Lisbon, Portugal., Alexeeva E; State Institution Scientific Center of Children Health of Rams Moscow, Moscow, Russian Federation., Chasnyk V; Saint-Petersburg State Pediatric Medical Academy, Saint-Petersburg, Russian Federation., Arkachaisri T; Translational Immunology Institute, Singapore, Singapore., Boyko Y; Western Ukrainian Specialized Children's Medical Centre, Lviv, Ukraine., Vyzhga Y; National Pirogov Memorial Medical University, Vinnytsia, Ukraine., Samsonenko S; Children's Regional Clinical Hospital in Dnipro, Dnipro, Ukraine.
Jazyk: angličtina
Zdroj: Journal of autoimmunity [J Autoimmun] 2024 Jul; Vol. 147, pp. 103265. Date of Electronic Publication: 2024 Jun 04.
DOI: 10.1016/j.jaut.2024.103265
Abstrakt: Objectives: The aim of the study was to establish an international multicenter registry to collect data on patients with Multisystem Inflammatory Syndrome in Children (MIS-C), in order to highlight a relationship between clinical presentation, age of onset and geographical distribution on the clinical outcome.
Study Design: Multicenter retrospective study involving different international societies for rare immunological disorders.1009 patients diagnosed with MIS-C between March and September 2022, from 48 centers and 22 countries were collected. Five age groups (<1, 1-4, 5-11, 12-16, >16 years) and four geographic macro-areas, Western Europe, Central-Eastern Europe, Latin America, Asian-African resource-limited countries (LRC), were identified.
Results: Time to referral was significantly higher in LRC. Intensive anti-inflammatory treatment, including biologics, respiratory support and mechanic ventilation were more frequently used in older children and in European countries. The mortality rate was higher in very young children (<1 year), in older patients (>16 years of age) and in LRC. Multivariate analysis identified the residence in LRC, presence of severe cardiac involvement, renal hypertension, lymphopenia and non-use of heparin prophylaxis, as the factors most strongly associated with unfavorable outcomes.
Conclusions: The stratification of patients by age and geographic macro-area provided insights into the clinical presentation, treatment and outcome of MIS-C. The mortality and sequelae rates exhibited a correlation with the age and geographical areas. Patients admitted and treated in LRC displayed more severe outcomes, possibly due to delays in hospital admission and limited access to biologic drugs and to intensive care facilities.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: