Impact of Cutaneous Squamous Cell Carcinoma Histologic Features on Percent Interrater Agreement Regarding Tumor Differentiation.

Autor:	Shahwan KT; Department of Dermatology, The Ohio State University Medical Center, Columbus, Ohio.; Department of Internal Medicine, University of North Dakota Medical School, Grand Forks, North Dakota.; Altru Health System, Grand Forks, North Dakota., Varra V; Department of Dermatology, The Ohio State University Medical Center, Columbus, Ohio., Nash J; Department of Dermatology, The Ohio State University Medical Center, Columbus, Ohio.; Transitional Year Residency Program, Kettering Health, Kettering, Ohio., Chung CG; Department of Dermatology, The Ohio State University Medical Center, Columbus, Ohio.; Department of Pathology, The Ohio State University Medical Center, Columbus, Ohio., Buckley KA; CORPath Ltd., Columbus, Ohio., McIlwee BE; Department of Dermatology, Springfield Clinic, Springfield, Illinois., Carr DR; Department of Dermatology, The Ohio State University Medical Center, Columbus, Ohio.
Jazyk:	angličtina
Zdroj:	Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] [Dermatol Surg] 2024 Jun 05. Date of Electronic Publication: 2024 Jun 05.
DOI:	10.1097/DSS.0000000000004275
Abstrakt:	Background: Poor differentiation predicts adverse outcomes in cutaneous squamous cell carcinoma (CSCC), but there is no standardized, reliable grading system. Objective: To explore which histologic features have the greatest impact on CSCC differentiation interrater agreement. Materials and Methods: In a prior study, 40 raters graded differentiation for 45 squamous cell carcinomas, and percent interrater agreements were calculated. Cases graded as well/moderately differentiated with 100% agreement (10), those graded as poorly differentiated with ≥80% agreement (5), and those that received a variety of grades with ≤60% agreement (7) were pulled for the current study. Three raters graded individual histologic features for each case, and percent interrater agreements were calculated using both the well/moderately/poorly differentiated grading system and a dichotomized system. Results: The percent interrater agreements were 34.8% for mitoses, 53% for pleomorphism, 59.1% for keratinization, 66.7% for cellular cohesion/intercellular bridges, and 78.8% for tumor edges. Percent agreements improved with dichotomous grading; the largest improvement was seen within the group of cases that had been graded as well/moderately differentiated with 100% agreement in the prior study. Conclusion: Future squamous cell carcinoma differentiation grading systems would benefit from eliminating mitotic rate, clearly defining how to grade other features, and dichotomous grading. (Copyright © 2024 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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