Tubular biomarkers and histology in lupus nephritis.

Autor: Carbayo J; Department of Nephrology, Hospital General Universitario Gregorio Marañón, Madrid, Spain., Verdalles Ú; Department of Nephrology, Hospital General Universitario Gregorio Marañón, Madrid, Spain., Díaz-Crespo F; Department of Pathology, Hospital General Universitario Gregorio Marañón, Madrid, Spain., Lázaro A; Renal Pathophysiology Laboratory, Instituto Investigación Sanitaria Gregorio Marañón, Madrid, Spain., González-Nicolás M; Renal Pathophysiology Laboratory, Instituto Investigación Sanitaria Gregorio Marañón, Madrid, Spain., Arroyo D; Department of Nephrology, Hospital General Universitario Gregorio Marañón, Madrid, Spain., Blanco D; Renal Pathophysiology Laboratory, Instituto Investigación Sanitaria Gregorio Marañón, Madrid, Spain., Redondo VC; Department of Pathology, Hospital General Universitario Gregorio Marañón, Madrid, Spain., García-Gámiz M; Clinical Biochemistry Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain., Goicoechea M; Department of Nephrology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Jazyk: angličtina
Zdroj: International journal of rheumatic diseases [Int J Rheum Dis] 2024 Jun; Vol. 27 (6), pp. e15210.
DOI: 10.1111/1756-185X.15210
Abstrakt: Introduction: The relevance of tubulo-interstitial involvement for kidney prognosis has recently been emphasized, but validated biomarkers for predicting histology are still lacking. The aim of our study was to evaluate different serum and urinary markers of tubular damage in patients with lupus nephritis (LN) and to correlate them with kidney histopathology.
Methods: A single-center retrospective study was conducted from January 2016 to December 2021. Serum and urine samples were collected on the same day of kidney biopsy and correlated with histologic data from a cohort of 15 LN patients. We analyzed the following urinary markers, adjusted for urine creatinine: beta 2-microglobulin, alpha 1-microglobulin, NGAL, uKIM-1, MCP-1, uDKK-3, and uUMOD. The serum markers sKIM-1 and sUMOD were also analyzed.
Results: A positive and strong correlation was observed between the degree of interstitial fibrosis (rho = 0.785, p = .001) and tubular atrophy (rho = 0.781, p = .001) and the levels of uDKK3. uUMOD also showed an inverse and moderate correlation with interstitial fibrosis (rho = -0.562, p = .037) and tubular atrophy (rho = -0.694, p = .006). Patients with >10% cortical interstitial inflammation had higher levels of uKIM-1 [4.9 (3.9, 5.5) vs. 0.8 (0.6, 1.5) mcg/mg, p = .001], MCP-1 [3.8 (2. 3, 4.2) vs. 0.7 (0.3, 1.2) mcg/mg, p = .001], sKIM-1 [9.2 (5.9, 32.7) vs. 1.4 (0, 3.5) pg/mL, p = .001], and lower sUMOD [8.7 (0, 39.7) vs. 46.1 (35.7, 53) ng/mL, p = .028].
Conclusion: The use of specific urinary and serum biomarkers of tubular dysfunction or injury may help to predict certain histologic parameters in LN patients.
(© 2024 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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