Clinical course of ulcerative colitis: Frequent use of biologics and low colectomy rate first year after diagnosis-results from the IBSEN III inception cohort.

Autor: Strande V; Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Lund C; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Public Health, Oslo Metropolitan University, Oslo, Norway., Hagen M; Department of Public Health, Oslo Metropolitan University, Oslo, Norway.; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway., Bengtson MB; Department of Gastroenterology, Vestfold Hospital Trust, Tønsberg, Norway., Cetinkaya RB; Department of Internal Medicine, Diakonhjemmet Hospital, Oslo, Norway., Detlie TE; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway., Frigstad SO; Department of Internal Medicine, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway., Høie O; Department of Internal Medicine, Hospital of Southern Norway, Arendal, Norway., Medhus AW; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway., Henriksen M; Department of Gastroenterology, Østfold Hospital Trust, Sarpsborg, Norway., Aass Holten KI; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Østfold Hospital Trust, Sarpsborg, Norway., Hovde Ø; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Internal Medicine, Innlandet Hospital Trust, Gjøvik, Norway., Huppertz-Hauss G; Department of Gastroenterology, Telemark Hospital Trust, Skien, Norway., Johansen I; Faculty of Health, Welfare and Org., Østfold University College, Fredrikstad, Norway.; Department of Public Health Science, Institute of Health and Society, University of Oslo, Oslo, Norway., Olsen BC; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Telemark Hospital Trust, Skien, Norway., Opheim R; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway.; Department of Public Health Science, Institute of Health and Society, University of Oslo, Oslo, Norway., Ricanek P; Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway.; Department of Gastroenterology, Lovisenberg Diaconal Hospital, Oslo, Norway., Torp R; Department of Internal Medicine, Innlandet Hospital Trust, Hamar, Norway., Tønnessen T; Department of Internal Medicine, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway., Vatn S; Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway., Aabrekk TB; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Vestfold Hospital Trust, Tønsberg, Norway., Høivik ML; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway., Kristensen VA; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway.
Jazyk: angličtina
Zdroj: Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2024 Aug; Vol. 60 (3), pp. 357-368. Date of Electronic Publication: 2024 Jun 04.
DOI: 10.1111/apt.18097
Abstrakt: Background: The introduction of biologic therapies and the 'treat-to-target' treatment strategy may have changed the disease course of ulcerative colitis (UC).
Aims: To describe the early disease course and disease outcome at 1-year follow-up in a population-based inception cohort of adult patients with newly diagnosed UC.
Methods: The Inflammatory Bowel Disease in South-Eastern Norway (IBSEN) III study is a population-based inception cohort study with prospective follow-up. Patients newly diagnosed with inflammatory bowel disease during 2017-2019 were included. Patients ≥18 years at diagnosis of UC who attended the 1-year follow-up were investigated. We registered clinical, endoscopic and demographic data at diagnosis and 1-year follow-up.
Results: We included 877 patients with UC (median age 36 years (range: 18-84), 45.8% female). At diagnosis, 39.2% presented with proctitis, 24.7% left-sided colitis and 36.0% extensive colitis. At the 1-year follow-up, 13.9% experienced disease progression, and 14.5% had received one or more biologic therapies. The colectomy rate was 0.9%. Steroid-free clinical remission was observed in 76.6%, and steroid-free endoscopic remission in 68.7%. Anaemia and initiation of systemic steroid treatment at diagnosis were associated with biologic therapy within the first year after diagnosis.
Conclusion: In this population-based inception cohort, colectomy rate in the first year after diagnosis was low, and a high proportion of patients were in remission at 1-year follow-up. The use of biologic therapy increases, consistent with findings from previous studies.
(© 2024 The Author(s). Alimentary Pharmacology & Therapeutics published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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