Micronutrient (iron, selenium, vitamin D) supplementation and the gut microbiome.

Autor:	Faradina A; School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan., Tinkov AA; Center of Bioelementology and Human Ecology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow.; Laboratory of Ecobiomonitoring and Quality Control, Yaroslavl State University, Yaroslavl.; Institute of Cellular and Intracellular Symbiosis, Russian Academy of Sciences, Orenburg, Russia., Skalny AV; Center of Bioelementology and Human Ecology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow.; Laboratory of Ecobiomonitoring and Quality Control, Yaroslavl State University, Yaroslavl., Chang JS; School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University.; Nutrition Research Center, Taipei Medical University Hospital.; Chinese Taipei Society for the Study of Obesity, CTSSO.; TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, Taiwan.
Jazyk:	angličtina
Zdroj:	Current opinion in clinical nutrition and metabolic care [Curr Opin Clin Nutr Metab Care] 2024 Sep 01; Vol. 27 (5), pp. 421-427. Date of Electronic Publication: 2024 May 21.
DOI:	10.1097/MCO.0000000000001046
Abstrakt:	Purpose of Review: Deficiencies in micronutrients persist as widespread global challenges, where supplementation remains a crucial therapeutic approach. This review aims to elucidate the intricate relationships between micronutrient supplementation - specifically iron, selenium (Se), and vitamin D (Vit D) - and gut microbiota composition, investigating their collective impact on host health and disease susceptibility. Recent Findings: Maintaining balanced iron levels is essential for gut microbiota equilibrium and host health, as both iron deficiency and excess disrupt gut bacterial balance, affecting colon health. Se supplementation can restore and improve the gut microbial balance, influencing health outcomes not only in the gut but also in areas such as neuroprotection in the brain, testicular health, and metabolic syndrome. Clinical and experimental models demonstrate that Vit D modulates the gut microbiome, enhancing anti-inflammatory effects, supporting metabolic health, and potentially reducing the risk of gut-related behavioral changes and diseases. Summary: Findings of this review emphasize that balanced iron levels are essential for maintaining a healthy gut microbiota composition and underscore the beneficial effects of Se and Vit D in modulating the gut microbiome. The interactions between micronutrients and the gut microbiome are complex but may have a broad spectrum of health outcomes. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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