Long-term, home-based transcranial direct current stimulation coupled with computerized cognitive training in frontotemporal dementia: A case report.

Autor:	Tippett DC; Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Neophytou K; Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Tao Y; Department of Cognitive Science, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD, USA., Gallegos J; Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Morrow C; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Onyike CU; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Tsapkini K; Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jazyk:	angličtina
Zdroj:	Journal of central nervous system disease [J Cent Nerv Syst Dis] 2024 Jun 03; Vol. 16, pp. 11795735241258435. Date of Electronic Publication: 2024 Jun 03 (Print Publication: 2024).
DOI:	10.1177/11795735241258435
Abstrakt:	We present the case of a 62-year-old woman with probable behavioral variant of frontotemporal dementia (bvFTD) with cognitive/language deficits who demonstrated improved performance on cognitive/language testing and in functional tasks following long-term, home-based transcranial direct current stimulation (tDCS) coupled with computerized cognitive training (CCT). The patient underwent home-based tDCS (anode on the left prefrontal cortex and cathode on the right homologue) for 46 sessions over 10 weeks along with CCT. On post-treatment testing, the patient improved by 3 points on the Mini-Mental State Exam (MMSE) (23 to 26). She also showed improvement on several cognitive/language tasks, such as immediate recall of single words and word pairs, total accurate words in sentence repetition, delayed recall, semantic processing, and sentence level comprehension. There was no decline in several other cognitive and language tasks. Family members reported subjective improvements in expressiveness, communication, and interaction with others as well as increased attention to grooming and style which contrasted with her pre-treatment condition. This report suggests that home-based tDCS combined with CCT for an extended period may slow decline, and improve cognitive/language performance and everyday function in FTD. Competing Interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Donna Tippett receives salary support from NIH NIA R01AG068881, R01AG075404, R01AG075111. Kyriaki Neophytou receives salary support from NIH NIA R01AG068881, R01AG075404, R01AG075111. Yuan Tao receives salary support from NIH NIA R01AG068881and R01AG075404. Jessica Gallegos receives salary support from NIH NIA R01AG068881, R01AG075404, R01AG075111. Christopher Morrow receives salary support from NIH KL2TR003099. Chiadi Onyike receives research funding from Alector Inc., Transposon Therapeutics, and Denali Therapeutics and is a consultant for Eisai, Otsuka, Reata. (© The Author(s) 2024.)
Databáze:	MEDLINE
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