The clinical course of individuals with 22q11.2 deletion syndrome converting to psychotic disorders: a long-term retrospective follow-up.

Autor: Kulikova K; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; The Pediatric Molecular Psychiatry Laboratory Sheba, Tel Hashomer, Israel.; The Behavioural Neurogenetics Center, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel., Schneider M; Clinical Psychology Unit for Intellectual and Developmental Disabilities, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland., McDonald McGinn DM; Division of Human Genetics, Department of Pediatrics, Perelman School of Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, USA.; Department of Human Biology and Medical Genetics, Sapienza University, Rome, Italy, Italy., Dar S; The Pediatric Molecular Psychiatry Laboratory Sheba, Tel Hashomer, Israel., Taler M; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; The Pediatric Molecular Psychiatry Laboratory Sheba, Tel Hashomer, Israel.; The Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel., Schwartz-Lifshitz M; The Behavioural Neurogenetics Center, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel.; The Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel., Eliez S; Developmental Imaging and Psychopathology lab, Department of Psychiatry, School of Medicine, University of Geneva, Geneva, Switzerland.; Department of Genetic Medicine and Development, School of Medicine, University of Geneva, Geneva, Switzerland., Gur RE; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Child and Adolescent Psychiatry, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Gothelf D; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel. gothelf@tauex.tau.ac.il.; The Behavioural Neurogenetics Center, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel. gothelf@tauex.tau.ac.il.; The Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. gothelf@tauex.tau.ac.il.
Jazyk: angličtina
Zdroj: European child & adolescent psychiatry [Eur Child Adolesc Psychiatry] 2024 Dec; Vol. 33 (12), pp. 4371-4379. Date of Electronic Publication: 2024 Jun 04.
DOI: 10.1007/s00787-024-02469-9
Abstrakt: Objectives: This retrospective study aims to investigate the evolution and clinical course of psychotic disorders from three large international cohorts of individuals with 22q11.2 deletion syndrome (22q11.2DS) (Tel Aviv, Philadelphia, and Geneva).
Methods: We followed 118 individuals with 22q11.2DS from several years before the onset to several years after the onset of psychotic disorders. Data from structured baseline assessment of psychiatric disorders, symptoms of prodrome, indicators and types of psychotic disorders were collected. Additionally, cognitive evaluation was conducted using the age-appropriate Wechsler Intelligence Scale. Electronic medical records were reviewed for medication usage, occupational status, living situation, and psychiatric hospitalizations.
Results: At baseline evaluation, the most common psychiatric disorders were anxiety disorder (80%) and attention/deficit hyperactivity disorder (50%). The age of onset of prodromal symptoms and conversion to psychotic disorders were 18.6 ± 6.8 and 20.3 ± 7.2, respectively. The most common prodromal symptoms were exacerbation of anxiety symptoms and social isolation. Of the psychotic disorders, schizophrenia was the most common, occurring in 49% of cases. History of at least one psychiatric hospitalization was present in 43% of participants, and the number of psychiatric hospitalizations was 2.1 ± 1.4. Compared to the normalized chart, IQ scores in our cohort were lower after vs. before conversion to psychosis. Following conversion there was a decrease in the use of stimulants and antidepressants and an increase in antipsychotics use, and most individuals with 22q11.2DS were unemployed and lived with their parents.
Conclusions: Our results indicate that 22q11.2DS psychosis is like non-22q11.2DS in its course, symptoms, and cognitive and functional impairments.
Competing Interests: Declarations. Conflict of interest: DMM is a member of the National Advisory Board for Natera. All other authors declare that they have no conflict of interest. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Sheba Medical Center (Date 07.04.2013 /No. 0303-13-SMC), the Commission Central d’Ethique de la Recherche (CCER) in Geneva (No. 2020–02296), and the review boards of the University of Pennsylvania and Children’s Hospital of Philadelphia (#832678). Consent to participate: Informed consent was obtained from all individual participants included in the study. Previous presentations: International Congress of the European Society for Child and Adolescent Psychiatry, 2023. Role of the sponsors: The funding source had no role in the study design, collection, analysis, or interpretation of data, the writing of the article, or the decision to submit the article for publication. Financial/non-financial interests: The authors have no relevant financial or non-financial interests to disclose. Competing interests: Donna M. McDonald McGinn is a member of the National Advisory Board for Natera.
(© 2024. Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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