The beneficial effects of ethanolic extract of Sargassum serratifolium in DNCB-induced mouse model of atopic dermatitis.

Autor: Kim MJ; Department of Food Science and Nutrition, Pukyong National University, 599-1, Daeyeondong, Nam-gu, Busan, 48513, Republic of Korea., Ryu H; Department of Food Science and Nutrition, Pukyong National University, 599-1, Daeyeondong, Nam-gu, Busan, 48513, Republic of Korea., Jeong HH; Department of Smart Green Technology Engineering, Pukyong National University, 599-1, Daeyeondong, Nam-gu, Busan, 48513, Republic of Korea., Van JY; Department of Smart Green Technology Engineering, Pukyong National University, 599-1, Daeyeondong, Nam-gu, Busan, 48513, Republic of Korea., Hwang JY; Department of Smart Green Technology Engineering, Pukyong National University, 599-1, Daeyeondong, Nam-gu, Busan, 48513, Republic of Korea., Kim AR; Department of Food Science and Nutrition, Pukyong National University, 599-1, Daeyeondong, Nam-gu, Busan, 48513, Republic of Korea., Seo J; Department of Smart Green Technology Engineering, Pukyong National University, 599-1, Daeyeondong, Nam-gu, Busan, 48513, Republic of Korea., Moon KM; Department of Food Science and Nutrition, Pukyong National University, 599-1, Daeyeondong, Nam-gu, Busan, 48513, Republic of Korea., Jung WK; Division of Biomedical Engineering and Research Center for Marine Integrated Bionics Technology, Pukyong National University, Busan, Republic of Korea.; Marine Integrated Biomedical Technology Center, The National Key Research Institutes, Pukyong National University, Busan, 48513, Republic of Korea., Lee B; Department of Food Science and Nutrition, Pukyong National University, 599-1, Daeyeondong, Nam-gu, Busan, 48513, Republic of Korea. bong3257@pknu.ac.kr.; Department of Smart Green Technology Engineering, Pukyong National University, 599-1, Daeyeondong, Nam-gu, Busan, 48513, Republic of Korea. bong3257@pknu.ac.kr.; Marine Integrated Biomedical Technology Center, The National Key Research Institutes, Pukyong National University, Busan, 48513, Republic of Korea. bong3257@pknu.ac.kr.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Jun 05; Vol. 14 (1), pp. 12874. Date of Electronic Publication: 2024 Jun 05.
DOI: 10.1038/s41598-024-62828-z
Abstrakt: Atopic dermatitis is a chronic complex inflammatory skin disorder that requires sustainable treatment methods due to the limited efficacy of conventional therapies. Sargassum serratifolium, an algal species with diverse bioactive substances, is investigated in this study for its potential benefits as a therapeutic agent for atopic dermatitis. RNA sequencing of LPS-stimulated macrophages treated with ethanolic extract of Sargassum serratifolium (ESS) revealed its ability to inhibit a broad range of inflammation-related signaling, which was proven in RAW 264.7 and HaCaT cells. In DNCB-induced BALB/c or HR-1 mice, ESS treatment improved symptoms of atopic dermatitis within the skin, along with histological improvements such as reduced epidermal thickness and infiltration of mast cells. ESS showed a tendency to improve serum IgE levels and inflammation-related cytokine changes, while also improving the mRNA expression levels of Chi3l3, Ccr1, and Fcεr1a genes in the skin. Additionally, ESS compounds (sargachromanol (SCM), sargaquinoic acid (SQA), and sargahydroquinoic acid (SHQA)) mitigated inflammatory responses in LPS-treated RAW264.7 macrophages. In summary, ESS has an anti-inflammatory effect and improves atopic dermatitis, ESS may be applied as a therapeutics for atopic dermatitis.
(© 2024. The Author(s).)
Databáze: MEDLINE
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