Associations between HIV stigma and health-related quality-of-life among people living with HIV: cross-sectional analysis of data from HPTN 071 (PopART).

Autor: Hall E; MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.; Abdul Latif Jameel Institute for Disease and Emergency Analytics, School of Public Health, Imperial College London, London, UK., Davis K; MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK. k.davis18@imperial.ac.uk.; Abdul Latif Jameel Institute for Disease and Emergency Analytics, School of Public Health, Imperial College London, London, UK. k.davis18@imperial.ac.uk., Ohrnberger J; MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.; Abdul Latif Jameel Institute for Disease and Emergency Analytics, School of Public Health, Imperial College London, London, UK., Pickles M; MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.; Abdul Latif Jameel Institute for Disease and Emergency Analytics, School of Public Health, Imperial College London, London, UK., Gregson S; MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.; Abdul Latif Jameel Institute for Disease and Emergency Analytics, School of Public Health, Imperial College London, London, UK., Thomas R; Department of Health Policy, London School of Economics, London, UK., Hargreaves JR; Department of Public Health, Environments and Society, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK., Pliakas T; Department of Public Health, Environments and Society, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK., Bwalya J; Zambart, School of Medicine, University of Zambia, Lusaka, Zambia., Dunbar R; Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health, University of Stellenbosch, Cape Town, South Africa., Mainga T; Zambart, School of Medicine, University of Zambia, Lusaka, Zambia.; Department of Global Health and Development, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK., Shanaube K; Zambart, School of Medicine, University of Zambia, Lusaka, Zambia., Hoddinott G; Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health, University of Stellenbosch, Cape Town, South Africa., Bond V; Zambart, School of Medicine, University of Zambia, Lusaka, Zambia.; Department of Global Health and Development, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK., Bock P; Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health, University of Stellenbosch, Cape Town, South Africa., Ayles H; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK., Stangl AL; Hera Solutions, Baltimore, MD, USA.; Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA., Donnell D; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Hayes R; Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK., Fidler S; Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK., Hauck K; MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.; Abdul Latif Jameel Institute for Disease and Emergency Analytics, School of Public Health, Imperial College London, London, UK.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Jun 04; Vol. 14 (1), pp. 12835. Date of Electronic Publication: 2024 Jun 04.
DOI: 10.1038/s41598-024-63216-3
Abstrakt: People living with HIV (PLHIV) report lower health-related quality-of-life (HRQoL) than HIV-negative people. HIV stigma may contribute to this. We explored the association between HIV stigma and HRQoL among PLHIV. We used cross-sectional data from 3991 randomly selected PLHIV who were surveyed in 2017-2018 for HPTN 071 (PopART), a cluster randomised trial in Zambia and South Africa. Participants were 18-44 years, had laboratory-confirmed HIV infection, and knew their status. HRQoL was measured using the EuroQol-5-dimensions-5-levels (EQ-5D-5L) questionnaire. Stigma outcomes included: internalised stigma, stigma experienced in the community, and stigma experienced in healthcare settings. Associations were examined using logistic regression. Participants who had experienced community stigma (n = 693/3991) had higher odds of reporting problems in at least one HRQoL domain, compared to those who had not (adjusted odds ratio, aOR: 1.51, 95% confidence interval, 95% Cl: 1.16-1.98, p = 0.002). Having experienced internalised stigma was also associated with reporting problems in at least one HRQoL domain (n = 552/3991, aOR: 1.98, 95% CI: 1.54-2.54, p < 0.001). However, having experienced stigma in a healthcare setting was less common (n = 158/3991) and not associated with HRQoL (aOR: 1.04, 95% CI: 0.68-1.58, p = 0.850). A stronger focus on interventions for internalised stigma and stigma experienced in the community is required.
(© 2024. The Author(s).)
Databáze: MEDLINE
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