Exploring the physicochemical traits, antifungal capabilities, and 3D spatial complexity of hydroxyapatite with Ag + Mg 2+ substitution in the biocomposite thin films.

Autor: Predoi D; National Institute of Materials Physics, Atomistilor Street, No. 405A, P.O. Box MG 07, Magurele 077125, Romania., Ţălu Ş; The Directorate of Research, Development and Innovation Management (DMCDI), Technical University of Cluj-Napoca, 15 Constantin Daicoviciu St., Cluj-Napoca, Cluj 400020, Romania. Electronic address: stefan_ta@yahoo.com., Carmen Ciobanu S; National Institute of Materials Physics, Atomistilor Street, No. 405A, P.O. Box MG 07, Magurele 077125, Romania., Iconaru SL; National Institute of Materials Physics, Atomistilor Street, No. 405A, P.O. Box MG 07, Magurele 077125, Romania., Saraiva Matos R; Amazonian Materials Group, Physics Department, Federal University of Amapá (UNIFAP), Macapá, Amapá 68903-419, Brazil., Duarte da Fonseca Filho H; Laboratory of Synthesis of Nanomaterials and Nanoscopy (LSNN), Physics Department, Federal University of Amazonas - UFAM, Manaus, Amazonas 69067-005, Brazil.
Jazyk: angličtina
Zdroj: Micron (Oxford, England : 1993) [Micron] 2024 Sep; Vol. 184, pp. 103661. Date of Electronic Publication: 2024 May 22.
DOI: 10.1016/j.micron.2024.103661
Abstrakt: The silver/magnesium doped hydroxyapatite (AgMgHAp, Ca 10-x-y Ag x Mg y (PO 4 ) 6 (OH) 2 , x Ag =0.05 and y Mg =0.02) nanocomposites coatings were deposited on Si substrate using the dip coating technique. The resulting coatings were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), Fourier transform infrared (FTIR-ATR) spectroscopy, atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS). The EDS analysis highlighted the presence of the constitutive elements of the silver/magnesium doped hydroxyapatite (AgMgHAp) nanocomposites coatings. The surface microtexture of the AgMgHAp was assessed by atomic force microscopy (AFM) technique. The AFM data suggested the obtaining of a uniform deposited layer comprised of equally distributed nanoconglomerates. FT-IR studies highlighted the presence of vibrational modes associated with the phosphate and hydroxyl groups. No bands associated with silver or magnesium were observed. The XPS analysis highlighted the presence of the constituent elements of hydroxyapatite (Ca 2p, P 2 s, O 1 s), as well as dopants (Ag 3d, Mg 1 s and Mg 2p). The antifungal evaluation of AgMgHAp coatings was carried out using the Candida albicans ATCC 10231 fungal strain. The results of the antifungal assay revealed that the AgMgHAp coatings exhibited a strong inhibitory antifungal activity. Furthermore, the data highlighted that the AgMgHAp inhibited the development of biofilm on their surface. The results revealed that the antifungal activity of the coating varied based on the duration of incubation. On the other hand, the data also showed that AgMgHAp nanocomposites coatings inhibited the fungal cell adhesion and development from the early stages of the incubation. In addition to morphological analysis, we additionally take advantage of AFM images to investigate and explore the domain of fractal and multifractal analysis applied to the films under evaluation. Our studies indicates that nanocomposite coatings made from AgMgHAp demonstrate strong antifungal properties. Our studies indicates that nanocomposite coatings made from AgMgHAp demonstrate strong antifungal properties. These results suggest the potential of AgMgHAp nanocomposite coatings as a promising solution for developing innovative antifungal devices in biomedical applications.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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