[ 18 F]FDG PET/CT versus [ 18 F]FDG PET/MRI in the evaluation of liver metastasis in patients with primary cancer: A head-to-head comparative meta-analysis.

Autor: Shi Y; Department of Graduate College, Hebei Medical University, Shijiazhuang 050011, China; Department of Hepatobiliary Surgery, Hebei General Hospital, Shijiazhuang 050051, China., Yu H; Department of Hepatobiliary Surgery, Hebei General Hospital, Shijiazhuang 050051, China., Zhang X; Department of Hepatobiliary Surgery, Hebei General Hospital, Shijiazhuang 050051, China; Department of Graduate college, North China University of Science and Technology, Tangshan 063210,China., Xu X; Department of Hepatobiliary Surgery, Hebei General Hospital, Shijiazhuang 050051, China; Department of Graduate college, North China University of Science and Technology, Tangshan 063210,China., Tuo H; Department of Hepatobiliary Surgery, Hebei General Hospital, Shijiazhuang 050051, China. Electronic address: tuohongfang2023@163.com.
Jazyk: angličtina
Zdroj: Clinical imaging [Clin Imaging] 2024 Aug; Vol. 112, pp. 110209. Date of Electronic Publication: 2024 May 31.
DOI: 10.1016/j.clinimag.2024.110209
Abstrakt: Purpose: This meta-analysis aimed to compare the diagnostic effectiveness of [ 18 F]FDG PET/CT with that of [ 18 F]FDG PET/MRI in terms of identifying liver metastasis in patients with primary cancer.
Methods: PubMed, Embase, Web of Science, and the Cochrane Library were searched, and studies evaluating the diagnostic efficacy of [ 18 F]FDG PET/CT and [ 18 F]FDG PET/MRI in patients with liver metastasis of primary cancer were included. We used a random effects model to analyze their sensitivity and specificity. Subgroup analyses and corresponding meta-regressions focusing on race, image analysis, study design, and analysis methodologies were conducted. Cochrane Q and I 2 statistics were used to assess intra-group and inter-group heterogeneity.
Results: Seven articles with 343 patients were included in this meta-analysis. The sensitivity of [ 18 F]FDG PET/CT was 0.82 (95 % CI: 0.63-0.96), and that of [ 18 F]FDG PET/MRI was 0.91 (95 % CI: 0.82-0.98); there was no significant difference between the two methods (P = 0.32). Similarly, both methods showed equal specificity: 1.00 (95 % CI: 0.95-1.00) for [ 18 F]FDG PET/CT and 1.00 (95 % CI: 0.96-1.00) for [ 18 F]FDG PET/MRI, and thus, there was no significant difference between the methods (P = 0.41). Furthermore, the subgroup analyses revealed no differences. Meta-regression analysis revealed that race was a potential source of heterogeneity for [ 18 F]FDG PET/CT (P = 0.01), while image analysis and contrast agent were found to be potential sources of heterogeneity for [18F]FDG PET/MRI (P = 0.02).
Conclusions: [ 18 F]FDG PET/MRI has similar sensitivity and specificity to [ 18 F]FDG PET/CT for detecting liver metastasis of primary cancer in both the general population and in subgroups. [ 18 F]FDG PET/CT may be a more cost-effective option. However, the conclusions of this meta-analysis are tentative due to the limited number of studies included, and further research is necessary for validation.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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