The Impact of Acute Exercise on Hemostasis and Angiogenesis Mediators in Patients With Continuous-Flow Left Ventricular Assist Devices: A Prospective Observational Pilot Study.

Autor:	Chan CHH; From the Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.; School of Engineering and Built Environment, Griffith University, Gold Coast, Australia.; Faculty of Medicine, University of Queensland, Brisbane, Australia.; Innovative Device & Engineering Applications Laboratory, Texas Heart Institute, Houston, Texas., Passmore MR; From the Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.; Faculty of Medicine, University of Queensland, Brisbane, Australia., Tronstad O; From the Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.; Physiotherapy Department, The Prince Charles Hospital, Brisbane, Australia., Seale H; Physiotherapy Department, The Prince Charles Hospital, Brisbane, Australia., Bouquet M; From the Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.; Faculty of Medicine, University of Queensland, Brisbane, Australia., White N; From the Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.; School of Public Health and Social Work, Queensland University of Technology, Brisbane, Australia., Teruya J; Departments of Pathology & Immunology, Pediatrics, and Medicine, Baylor College of Medicine, Houston, Texas., Hogan A; Department of Cardiology, The Prince Charles Hospital, Brisbane, Australia., Platts D; Department of Cardiology, The Prince Charles Hospital, Brisbane, Australia., Chan W; Department of Cardiology, The Prince Charles Hospital, Brisbane, Australia.; Cardio-Vascular Molecular and Therapeutics Translational Research Group, University of Queensland, Brisbane, Australia., Dashwood AM; Department of Cardiology, The Prince Charles Hospital, Brisbane, Australia.; Cardio-Vascular Molecular and Therapeutics Translational Research Group, University of Queensland, Brisbane, Australia., McGiffin DC; From the Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.; Department of Cardiothoracic Surgery and Transplantation, The Alfred Hospital, Melbourne, Australia.; Department of Cardiothoracic Surgery, Monash University, Melbourne, Australia., Maiorana AJ; Allied Health Department, Fiona Stanley Hospital, Perth, Australia.; Curtin School of Allied Health, Curtin University, Perth, Australia., Hayward CS; Heart Failure and Transplant Unit, St. Vincent's Hospital, Sydney, Australia.; Victor Chang Cardiac Research Institute, Sydney, Australia., Simmonds MJ; Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia., Tansley GD; From the Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.; School of Engineering and Built Environment, Griffith University, Gold Coast, Australia., Suen JY; From the Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.; Faculty of Medicine, University of Queensland, Brisbane, Australia., Fraser JF; From the Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.; Faculty of Medicine, University of Queensland, Brisbane, Australia., Meyns B; Department of Cardiovascular Sciences, Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium; and., Fresiello L; Department of Cardiovascular Sciences, Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium; and.; Group of Cardiovascular and Respiratory Physiology, University of Twente, Enschede, The Netherlands., Jacobs S; Department of Cardiovascular Sciences, Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium; and.
Jazyk:	angličtina
Zdroj:	ASAIO journal (American Society for Artificial Internal Organs : 1992) [ASAIO J] 2024 Jun 05. Date of Electronic Publication: 2024 Jun 05.
DOI:	10.1097/MAT.0000000000002246
Abstrakt:	Impaired primary hemostasis and dysregulated angiogenesis, known as a two-hit hypothesis, are associated with gastrointestinal (GI) bleeding in patients with continuous-flow left ventricular assist devices (CF-LVADs). Exercise is known to influence hemostasis and angiogenesis in healthy individuals; however, little is known about the effect in patients with CF-LVADs. The objective of this prospective observational study was to determine whether acute exercise modulates two-hit hypothesis mediators associated with GI bleeding in patients with a CF-LVAD. Twenty-two patients with CF-LVADs performed acute exercise either on a cycle ergometer for approximately 10 minutes or on a treadmill for 30 minutes. Blood samples were taken pre- and post-exercise to analyze hemostatic and angiogenic biomarkers. Acute exercise resulted in an increased platelet count (p < 0.00001) and platelet function (induced by adenosine diphosphate, p = 0.0087; TRAP-6, p = 0.0005; ristocetin, p = 0.0009). Additionally, high-molecular-weight vWF multimers (p < 0.00001), vWF collagen-binding activity (p = 0.0012), factor VIII (p = 0.034), angiopoietin-1 (p = 0.0026), and vascular endothelial growth factor (p = 0.0041) all increased after acute exercise. This pilot work demonstrates that acute exercise modulated two-hit hypothesis mediators associated with GI bleeding in patients with CF-LVADs. Competing Interests: Disclosure: The authors have no conflicts of interest to report. (Copyright © ASAIO 2024.)
Databáze:	MEDLINE
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