Timing matters: diurnal variation of maximal fat oxidation and substrate oxidation rates in metabolic syndrome-a randomized crossover study.

Autor: Methnani J; High Institute of Sport and Physical Education, University of Manouba, Ksar Said, Tunis, Tunisia. Jabeur.methnani@gmail.com.; LR19ES09, Laboratoire de Physiologie de l'Exercice et Physiopathologie: de l'Intégré au Moléculaire Biologie, Médecine et Santé, Faculty of Medicine of Sousse, 4002, Sousse, Tunisia. Jabeur.methnani@gmail.com.; LR12SP11, Biochemistry Department, Sahloul University Hospital, Sousse, Tunisia. Jabeur.methnani@gmail.com., Brahim MM; High Institute of Sport and Physical Education, University of Manouba, Ksar Said, Tunis, Tunisia.; LR19ES09, Laboratoire de Physiologie de l'Exercice et Physiopathologie: de l'Intégré au Moléculaire Biologie, Médecine et Santé, Faculty of Medicine of Sousse, 4002, Sousse, Tunisia., Elhraiech A; Service of Cardiology, University of Sousse, Sahloul University Hospital, Sousse, Tunisia., Ach T; LR19ES09, Laboratoire de Physiologie de l'Exercice et Physiopathologie: de l'Intégré au Moléculaire Biologie, Médecine et Santé, Faculty of Medicine of Sousse, 4002, Sousse, Tunisia.; Service of Endocrinology, University of Sousse, Farhat HACHED University Hospital, Sousse, Tunisia., Latiri I; LR12SP09, Research Laboratory, Heart Failure, University of Sousse, Farhat HACHED University Hospital, Sousse, Tunisia.; Service of Physiology and Functional Explorations, University of Sousse, Farhat HACHED University Hospital, Sousse, Tunisia., Zaouali M; LR19ES09, Laboratoire de Physiologie de l'Exercice et Physiopathologie: de l'Intégré au Moléculaire Biologie, Médecine et Santé, Faculty of Medicine of Sousse, 4002, Sousse, Tunisia., Rouatbi S; LR12SP09, Research Laboratory, Heart Failure, University of Sousse, Farhat HACHED University Hospital, Sousse, Tunisia.; Service of Physiology and Functional Explorations, University of Sousse, Farhat HACHED University Hospital, Sousse, Tunisia., Bouslama A; LR12SP11, Biochemistry Department, Sahloul University Hospital, Sousse, Tunisia.; Faculty of Pharmacy of Monastir, University of Monastir, Monastir, Tunisia., Brun JF; PHYMEDEXP, Université de Montpellier, CNRS, INSERM, CHU de Montpellier, 34295, Montpellier, France., Omezzine A; LR12SP11, Biochemistry Department, Sahloul University Hospital, Sousse, Tunisia.; Faculty of Pharmacy of Monastir, University of Monastir, Monastir, Tunisia., Bouhlel E; High Institute of Sport and Physical Education, University of Manouba, Ksar Said, Tunis, Tunisia.; LR19ES09, Laboratoire de Physiologie de l'Exercice et Physiopathologie: de l'Intégré au Moléculaire Biologie, Médecine et Santé, Faculty of Medicine of Sousse, 4002, Sousse, Tunisia.
Jazyk: angličtina
Zdroj: European journal of applied physiology [Eur J Appl Physiol] 2024 Oct; Vol. 124 (10), pp. 3135-3145. Date of Electronic Publication: 2024 Jun 04.
DOI: 10.1007/s00421-024-05518-y
Abstrakt: Purpose: The aim of this study was to investigate if diurnal oscillation in maximal fat oxidation (MFO) and substrate oxidation rates during exercise exists in subjects with metabolic syndrome (MetS).
Methods: In a randomized crossover design, 14 MetS patients were assigned to two graded exercise tests conditions performed in the morning (between 7:00 and 9:00 a.m) and in the afternoon (between 4:00 and 5:00 p.m). MFO was defined as the highest absolute value of fat oxidation obtained from the average of last 2-min stages during an indirect calorimetry test.
Results: MFO increased by 20.6% from morning to afternoon (p = 0.0002, Cohen's d = 0.52). There was a significant time of day, (p < 0.0001, η 2 p = 0.76) and intensity effect (p = 0.002, η 2 p = 0.32) in fat oxidation (Fatox) rates indicating that Fatox was higher in the afternoon than in the morning.
Conclusion: Our study extends previous findings on the existence of diurnal variation in maximal fat oxidation to MetS patients, highlighting the afternoon as a more favorable time for fat utilization during exercise. These findings have practical implications for optimizing training timing in MetS patients.
Trial Registration Number: PACTR202306776991260.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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