HHV6-Associated Hydrocephalus in a Pediatric Hematopoietic Stem Cell Transplant Recipient: An Unusual Presentation.
| Autor: | Al Nuaimi M; Division of Pediatric Hematology and Oncology, Tawam Oncology Centre.; Department of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain., Al Khaaldi A; Department of Pediatrics, Al Qassimi Women and Children Hospital.; Sharjah University Hospital, Sharjah., Trad O; Division of Pediatric Hematology and Oncology, Tawam Oncology Centre., Almulla A; Division of Pediatric Hematology and Oncology, Tawam Oncology Centre.; Sharjah University Hospital, Sharjah., Al Rufaye H; Division of Pediatric Hematology and Oncology, Tawam Oncology Centre., Ghatasheh G; Department of Pediatrics, Division of Pediatric Infectious Diseases, Tawam Hospital., Al Dhaheri F; Department of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain.; Pediatric Infectious Diseases Unit, Department of Pediatrics, Sheikh Khalifa Medical City, Abu-Dhabi, United Arab Emirates. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2024 Aug 01; Vol. 46 (6), pp. e426-e429. Date of Electronic Publication: 2024 Jun 03. |
| DOI: | 10.1097/MPH.0000000000002892 |
| Abstrakt: | Human herpesvirus 6 (HHV-6) is a widely spread DNA virus that is ubiquitous and persistent with primary infection occurring in early childhood, with reactivation of the infection a common phenomenon in severely immunocompromised hosts, including hematopoietic stem cell transplant (HSCT) patients, influencing morbidity and mortality. A wide spectrum of clinical presentations is reported in the literature with HHV-6 reactivation including post-transplant limbic encephalitis (PALE). We report the unusual case of a 6-year-old female 107 days postallogenic HSCT due to transfusion dependent beta thalassemia major who developed acute cerebellitis with secondary supratentorial hydrocephalus that required invasive surgical intervention. In addition to accompanying imaging findings, the patient tested positive for HHV-6 by PCR from both serum and CSF samples and demonstrated dramatic improvement with the institution of steroid therapy in addition to ganciclovir treatment. The availability of rapid diagnostic measures in addition to a multidisciplinary approach is crucial to manage HHV-6 encephalitis and associated complications in HSCT patients. Competing Interests: The authors declare no conflict of interest. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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