Tumor thickness and depth of invasion in squamous cell carcinoma of tongue as indicators of the loco-regional spread of the disease: A preliminary study.

Autor: Das R; Department of Oral Medicine & Radiology, Institute of Dental Sciences, Siksha 'O' Anusandhan deemed to be University, Bhubaneswar, Odish, India., Misra SR; Department of Oral Medicine & Radiology, Institute of Dental Sciences, Siksha 'O' Anusandhan deemed to be University, Bhubaneswar, Odish, India., Mohapatra SSG; Department of Radiodiagnosis, Institute of Medical Sciences, Siksha 'O' Anusandhan deemed to be University, Bhubaneswar, Odisha, India., Bahinipati P; Department of Radiodiagnosis, Institute of Medical Sciences, Siksha 'O' Anusandhan deemed to be University, Bhubaneswar, Odisha, India., Rani Priyadarshini S; Department of Oral Medicine & Radiology, Institute of Dental Sciences, Siksha 'O' Anusandhan deemed to be University, Bhubaneswar, Odish, India., Sahoo A; Department of Oral Medicine & Radiology, Institute of Dental Sciences, Siksha 'O' Anusandhan deemed to be University, Bhubaneswar, Odish, India., Mishra D; Department of Pathology, Institute of Medical Sciences, Siksha 'O' Anusandhan deemed to be University, Bhubaneswar, Odisha, India., Rai A; Department of Oral Medicine & Radiology, Institute of Dental Sciences, Siksha 'O' Anusandhan deemed to be University, Bhubaneswar, Odish, India.
Jazyk: angličtina
Zdroj: Journal of oral biology and craniofacial research [J Oral Biol Craniofac Res] 2024 Jul-Aug; Vol. 14 (4), pp. 423-429. Date of Electronic Publication: 2024 May 24.
DOI: 10.1016/j.jobcr.2024.05.006
Abstrakt: Background: Magnetic resonance imaging (MRI) is a routinely used imaging modality for pre-treatment radiologic evaluation of tongue carcinoma, providing accurate information regarding the extent of the disease.
Aims and Objectives: To investigate the role of MRI-derived depth of invasion and tumor thickness evaluation in squamous cell carcinoma of the tongue, and to assess if any correlation exists between depth of invasion, tumor thickness, nodal metastasis, muscles, and space involved.
Materials and Methods: Thirty-three patients with oral squamous cell carcinoma of the tongue who had undergone pre-treatment MRI and excisional biopsy were included. The tumor thickness (TT) and depth of invasion (DOI) were evaluated on MRI and histopathologic images.
Result: The relation between different methodologies for assessing showed a very high correlation for the tumor tissue thickness (r = 0.99, p < 0.05) and depth of invasion (r = 0.82, p < 0.05). The tumor thickness and the depth of invasion increased with the loss of differentiation in the carcinoma histopathologically. As the depth of invasion increases, the extent of the spread of the carcinoma to tongue musculature, lingual septum, and spaces also increases.
Conclusion: The present study has depicted a high correlation between the tumor thickness and the depth of invasion between MRI and histopathological findings and is the first of its kind to correlate DOI to the invasiveness of the disease.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2024 Published by Elsevier B.V. on behalf of Craniofacial Research Foundation.)
Databáze: MEDLINE
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