Better together: nanoscale co-delivery systems of therapeutic agents for high-performance cancer therapy.

Autor:	Sun L; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Li Z; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; The MOE Innovation Centre for Basic Medicine Research on Qi-Blood TCM Theories, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Lan J; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; The MOE Innovation Centre for Basic Medicine Research on Qi-Blood TCM Theories, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Wu Y; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Zhang T; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; The MOE Innovation Centre for Basic Medicine Research on Qi-Blood TCM Theories, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Ding Y; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; The MOE Innovation Centre for Basic Medicine Research on Qi-Blood TCM Theories, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2024 May 20; Vol. 15, pp. 1389922. Date of Electronic Publication: 2024 May 20 (Print Publication: 2024).
DOI:	10.3389/fphar.2024.1389922
Abstrakt:	Combination therapies can enhance the sensitivity of cancer to drugs, lower drug doses, and reduce side effects in cancer treatment. However, differences in the physicochemical properties and pharmacokinetics of different therapeutic agents limit their application. To avoid the above dilemma and achieve accurate control of the synergetic ratio, a nanoscale co-delivery system (NCDS) has emerged as a prospective tool for combined therapy in cancer treatment, which is increasingly being used to co-load different therapeutic agents. In this study, we have summarized the mechanisms of therapeutic agents in combination for cancer therapy, nanoscale carriers for co-delivery, drug-loading strategies, and controlled/targeted co-delivery systems, aiming to give a general picture of these powerful approaches for future NCDS research studies. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Sun, Li, Lan, Wu, Zhang and Ding.)
Databáze:	MEDLINE
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