Evaluating drug interaction potential from cytokine release syndrome using a physiologically based pharmacokinetic model: A case study of teclistamab.
Autor: | Willemin ME; Janssen Research & Development, Beerse, Belgium., Wang Lin SX; Janssen Research & Development, Spring House, Pennsylvania, USA., De Zwart L; Janssen Research & Development, Beerse, Belgium., Wu LS; Janssen Research & Development, South San Francisco, California, USA., Miao X; Janssen Research & Development, Spring House, Pennsylvania, USA., Verona R; Janssen Research & Development, Spring House, Pennsylvania, USA., Banerjee A; Janssen Research & Development, Spring House, Pennsylvania, USA., Liu B; Janssen Research & Development, Raritan, New Jersey, USA., Kobos R; Janssen Research & Development, Raritan, New Jersey, USA., Qi M; Janssen Research & Development, Raritan, New Jersey, USA., Ouellet D; Janssen Research & Development, Spring House, Pennsylvania, USA., Goldberg JD; Janssen Research & Development, Raritan, New Jersey, USA., Girgis S; Janssen Research & Development, Spring House, Pennsylvania, USA. |
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Jazyk: | angličtina |
Zdroj: | CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2024 Jul; Vol. 13 (7), pp. 1117-1129. Date of Electronic Publication: 2024 Jun 03. |
DOI: | 10.1002/psp4.13144 |
Abstrakt: | Cytokine release syndrome (CRS) was associated with teclistamab treatment in the phase I/II MajesTEC-1 study. Cytokines, especially interleukin (IL)-6, are known suppressors of cytochrome P450 (CYP) enzymes' activity. A physiologically based pharmacokinetic model evaluated the impact of IL-6 serum levels on exposure of substrates of various CYP enzymes (1A2, 2C9, 2C19, 3A4, 3A5). Two IL-6 kinetics profiles were assessed, the mean IL-6 profile with a maximum concentration (C (© 2024 The Authors. CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.) |
Databáze: | MEDLINE |
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