Low-calorie diet-induced weight loss is associated with altered brain connectivity and food desire in obesity.

Autor: Hoang H; Department of Internal Medicine, Endocrinology Section, Yale University School of Medicine, New Haven, Connecticut, USA., Lacadie C; Department of Radiology, Yale University School of Medicine, New Haven, Connecticut, USA., Hwang J; Department of Internal Medicine, Endocrinology Section, Yale University School of Medicine, New Haven, Connecticut, USA.; Division of Endocrinology and Metabolism, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Lam K; Department of Internal Medicine, Endocrinology Section, Yale University School of Medicine, New Haven, Connecticut, USA., Elshafie A; Department of Internal Medicine, Endocrinology Section, Yale University School of Medicine, New Haven, Connecticut, USA., Rosenberg SB; Department of Health Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts, USA., Watt C; Department of Internal Medicine, Endocrinology Section, Yale University School of Medicine, New Haven, Connecticut, USA., Sinha R; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA., Constable RT; Department of Radiology, Yale University School of Medicine, New Haven, Connecticut, USA., Savoye M; Department of Pediatrics, Pediatric Endocrinology Section, Yale University School of Medicine, New Haven, Connecticut, USA., Seo D; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA., Belfort-DeAguiar R; Department of Internal Medicine, Endocrinology Section, Yale University School of Medicine, New Haven, Connecticut, USA.; Division of Diabetes, Long School of Medicine, University of Texas Health San Antonio, San Antonio, Texas, USA.
Jazyk: angličtina
Zdroj: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2024 Jul; Vol. 32 (7), pp. 1362-1372. Date of Electronic Publication: 2024 Jun 03.
DOI: 10.1002/oby.24046
Abstrakt: Objective: The main objective of this study is to better understand the effects of diet-induced weight loss on brain connectivity in response to changes in glucose levels in individuals with obesity.
Methods: A total of 25 individuals with obesity, among whom 9 had a diagnosis of type 2 diabetes, underwent functional magnetic resonance imaging (fMRI) scans before and after an 8-week low-calorie diet. We used a two-step hypereuglycemia clamp approach to mimic the changes in glucose levels observed in the postprandial period in combination with task-mediated fMRI intrinsic connectivity distribution (ICD) analysis.
Results: After the diet, participants lost an average of 3.3% body weight. Diet-induced weight loss led to a decrease in leptin levels, an increase in hunger and food intake, and greater brain connectivity in the parahippocampus, right hippocampus, and temporal cortex (limbic-temporal network). Group differences (with vs. without type 2 diabetes) were noted in several brain networks. Connectivity in the limbic-temporal and frontal-parietal brain clusters inversely correlated with hunger.
Conclusions: A short-term low-calorie diet led to a multifaceted body response in patients with obesity, with an increase in connectivity in the limbic-temporal network (emotion and memory) and hormone and eating behavior changes that may be important for recovering the weight lost.
(© 2024 The Obesity Society.)
Databáze: MEDLINE
Externí odkaz: