A guide to adaptive immune memory.

Autor: Lam N; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Lee Y; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Farber DL; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA. df2396@cumc.columbia.edu.; Department of Surgery, Columbia University Irving Medical Center, New York, NY, USA. df2396@cumc.columbia.edu.
Jazyk: angličtina
Zdroj: Nature reviews. Immunology [Nat Rev Immunol] 2024 Nov; Vol. 24 (11), pp. 810-829. Date of Electronic Publication: 2024 Jun 03.
DOI: 10.1038/s41577-024-01040-6
Abstrakt: Immune memory - comprising T cells, B cells and plasma cells and their secreted antibodies - is crucial for human survival. It enables the rapid and effective clearance of a pathogen after re-exposure, to minimize damage to the host. When antigen-experienced, memory T cells become activated, they proliferate and produce effector molecules at faster rates and in greater magnitudes than antigen-inexperienced, naive cells. Similarly, memory B cells become activated and differentiate into antibody-secreting cells more rapidly than naive B cells, and they undergo processes that increase their affinity for antigen. The ability of T cells and B cells to form memory cells after antigen exposure is the rationale behind vaccination. Understanding immune memory not only is crucial for the design of more-efficacious vaccines but also has important implications for immunotherapies in infectious disease and cancer. This 'guide to' article provides an overview of the current understanding of the phenotype, function, location, and pathways for the generation, maintenance and protective capacity of memory T cells and memory B cells.
(© 2024. Springer Nature Limited.)
Databáze: MEDLINE
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