SenNet recommendations for detecting senescent cells in different tissues.

Autor:	Suryadevara V; Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, School of Medicine, Stanford, CA, USA., Hudgins AD; Department of Obstetrics and Gynecology, Columbia University, New York, NY, USA., Rajesh A; Sanford Burnham Prebys Medical Discovery Institute, Cancer Genome and Epigenetics Program, La Jolla, CA, USA., Pappalardo A; Department of Dermatology, Columbia University, New York, NY, USA., Karpova A; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Dey AK; National Institute on Aging, NIH, Baltimore, MD, USA., Hertzel A; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA., Agudelo A; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA.; Center on the Biology of Aging, Brown University, Providence, RI, USA., Rocha A; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA.; Center on the Biology of Aging, Brown University, Providence, RI, USA., Soygur B; The Buck Institute for Research on Aging, Novato, CA, USA., Schilling B; The Buck Institute for Research on Aging, Novato, CA, USA., Carver CM; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Rochester, MN, USA., Aguayo-Mazzucato C; Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, Harvard Medical School, Boston, USA., Baker DJ; Robert and Arlene Kogod Center on Aging, Rochester, MN, USA.; Department of Biochemistry and Molecular Biology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA., Bernlohr DA; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA., Jurk D; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Rochester, MN, USA.; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Mangarova DB; Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, School of Medicine, Stanford, CA, USA., Quardokus EM; Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA., Enninga EAL; Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA., Schmidt EL; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA., Chen F; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Duncan FE; The Buck Institute for Research on Aging, Novato, CA, USA.; Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Cambuli F; New York Genome Center, New York, NY, USA., Kaur G; Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA., Kuchel GA; UConn Center on Aging, University of Connecticut Health Center, Farmington, CT, USA.; Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT, USA., Lee G; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Rochester, MN, USA., Daldrup-Link HE; Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, School of Medicine, Stanford, CA, USA., Martini H; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Rochester, MN, USA., Phatnani H; New York Genome Center, New York, NY, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Al-Naggar IM; UConn Center on Aging, University of Connecticut Health Center, Farmington, CT, USA., Rahman I; Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA., Nie J; Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Passos JF; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Rochester, MN, USA., Silverstein JC; Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Campisi J; The Buck Institute for Research on Aging, Novato, CA, USA., Wang J; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Iwasaki K; Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, Harvard Medical School, Boston, USA., Barbosa K; Sanford Burnham Prebys Medical Discovery Institute, Cancer Genome and Epigenetics Program, La Jolla, CA, USA., Metis K; Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Nernekli K; Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, School of Medicine, Stanford, CA, USA., Niedernhofer LJ; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.; Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA., Ding L; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Wang L; UConn Center on Aging, University of Connecticut Health Center, Farmington, CT, USA.; Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT, USA., Adams LC; Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, School of Medicine, Stanford, CA, USA., Ruiyang L; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Doolittle ML; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Rochester, MN, USA.; Division of Endocrinology, Diabetes and Metabolism, Mayo Clinic, Rochester, MN, USA., Teneche MG; Sanford Burnham Prebys Medical Discovery Institute, Cancer Genome and Epigenetics Program, La Jolla, CA, USA., Schafer MJ; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Rochester, MN, USA.; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Xu M; UConn Center on Aging, University of Connecticut Health Center, Farmington, CT, USA.; Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT, USA., Hajipour M; Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, School of Medicine, Stanford, CA, USA., Boroumand M; National Institute on Aging, NIH, Baltimore, MD, USA., Basisty N; National Institute on Aging, NIH, Baltimore, MD, USA., Sloan N; Department of Neurology, Columbia University Medical Center, New York, NY, USA., Slavov N; Center on the Biology of Aging, Brown University, Providence, RI, USA.; Department of Bioengineering, Northeastern University, Boston, MA, USA.; Department of Biology, Northeastern University, Boston, MA, USA.; Barnett Institute for Chemical and Biological Analysis, Northeastern University, Boston, MA, USA., Kuksenko O; Department of Neurology, Columbia University Medical Center, New York, NY, USA., Robson P; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; Institute for Systems Genomics, University of Connecticut, Farmington, CT, USA., Gomez PT; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Rochester, MN, USA., Vasilikos P; Department of Genetics and Development, Columbia University, New York, NY, USA., Adams PD; Sanford Burnham Prebys Medical Discovery Institute, Cancer Genome and Epigenetics Program, La Jolla, CA, USA., Carapeto P; Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, Harvard Medical School, Boston, USA., Zhu Q; Center for Epigenomics, University of California, San Diego, CA, USA., Ramasamy R; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Perez-Lorenzo R; Department of Dermatology, Columbia University, New York, NY, USA., Fan R; Yale-Center for Research on Aging, Yale School of Medicine, New Haven, CT, USA., Dong R; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, WA, USA., Montgomery RR; Yale-Center for Research on Aging, Yale School of Medicine, New Haven, CT, USA., Shaikh S; Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA., Vickovic S; New York Genome Center, New York, NY, USA.; Herbert Irving Institute for Cancer Dynamics, Columbia University, New York, NY, USA.; Department of Biomedical Engineering, Columbia University, New York, NY, USA.; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Beijer Laboratory for Gene and Neuro Research, Uppsala University, Uppsala, Sweden., Yin S; Sanford Burnham Prebys Medical Discovery Institute, Cancer Genome and Epigenetics Program, La Jolla, CA, USA., Kang S; Department of Biochemistry, University of Washington, Seattle, WA, USA., Suvakov S; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA., Khosla S; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Rochester, MN, USA.; Division of Endocrinology, Diabetes and Metabolism, Mayo Clinic, Rochester, MN, USA., Garovic VD; Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA.; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA., Menon V; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Translational and Computational Neuroimmunology, Columbia University Irving Medical Center, New York, NY, USA., Xu Y; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Song Y; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Suh Y; Department of Obstetrics and Gynecology, Columbia University, New York, NY, USA.; Department of Genetics and Development, Columbia University, New York, NY, USA., Dou Z; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Neretti N; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA. nicola_neretti@brown.edu.; Center on the Biology of Aging, Brown University, Providence, RI, USA. nicola_neretti@brown.edu.
Jazyk:	angličtina
Zdroj:	Nature reviews. Molecular cell biology [Nat Rev Mol Cell Biol] 2024 Dec; Vol. 25 (12), pp. 1001-1023. Date of Electronic Publication: 2024 Jun 03.
DOI:	10.1038/s41580-024-00738-8
Abstrakt:	Once considered a tissue culture-specific phenomenon, cellular senescence has now been linked to various biological processes with both beneficial and detrimental roles in humans, rodents and other species. Much of our understanding of senescent cell biology still originates from tissue culture studies, where each cell in the culture is driven to an irreversible cell cycle arrest. By contrast, in tissues, these cells are relatively rare and difficult to characterize, and it is now established that fully differentiated, postmitotic cells can also acquire a senescence phenotype. The SenNet Biomarkers Working Group was formed to provide recommendations for the use of cellular senescence markers to identify and characterize senescent cells in tissues. Here, we provide recommendations for detecting senescent cells in different tissues based on a comprehensive analysis of existing literature reporting senescence markers in 14 tissues in mice and humans. We discuss some of the recent advances in detecting and characterizing cellular senescence, including molecular senescence signatures and morphological features, and the use of circulating markers. We aim for this work to be a valuable resource for both seasoned investigators in senescence-related studies and newcomers to the field. Competing Interests: Competing interests: The authors declare the following competing interests: J.C. is a founder and shareholder of Unity Biotechnology, which develops senolytic drugs. M.J.S., C.M.C. and Mayo Clinic have intellectual property related to this research. Research in the M.J.S. and D.J.B. laboratory is reviewed by the Mayo Clinic Conflict of Interest Review Board and conducted in compliance with Mayo Clinic Conflict of Interest policies. D.J.B. has a potential financial interest related to this research; he is a co-inventor on patents held by Mayo Clinic and patent applications licensed to or filed by Unity Biotechnology and a Unity Biotechnology shareholder. N. Slavov is a founding director and CEO of Parallel Squared Technology Institute, which is a non-profit research institute. (© 2024. Springer Nature Limited.)
Databáze:	MEDLINE
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