Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease.

Autor: Salihovic S; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Nyström N; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden., Mathisen CB; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway., Kruse R; Department of Clinical Research Laboratory, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Olbjørn C; Department of Pediatrics and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway., Andersen S; Department of Pediatrics, Vestfold Hospital Trust, Tønsberg, Norway., Noble AJ; Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom.; Biomedical Research Center, University of Oxford, Oxford, United Kingdom., Dorn-Rasmussen M; Department of Paediatric and Adolescence Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark., Bazov I; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Perminow G; Department of Pediatric Medicine, Oslo University Hospital, Oslo, Norway., Opheim R; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway., Detlie TE; Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway., Huppertz-Hauss G; Department of Gastroenterology, Telemark Hospital Trust, Skien, Norway., Hedin CRH; Karolinska Institutet, Department of Medicine Solna, Stockholm, Sweden.; Karolinska University Hospital, Gastroenterology unit, Department of Gastroenterology, Dermatovenereology and Rheumatology, Stockholm, Sweden., Carlson M; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Öhman L; Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Magnusson MK; Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Keita ÅV; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Söderholm JD; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., D'Amato M; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain.; Department of Medicine & Surgery, LUM University, Casamassima, Italy., Orešič M; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland., Wewer V; Department of Paediatric and Adolescence Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark., Satsangi J; Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom.; Biomedical Research Center, University of Oxford, Oxford, United Kingdom., Lindqvist CM; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Burisch J; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.; Gastrounit, medical division, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark., Uhlig HH; Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom.; Biomedical Research Center, University of Oxford, Oxford, United Kingdom.; Department of Paediatrics, University of Oxford, Oxford, UK., Repsilber D; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Hyötyläinen T; School of Science and Technology, Örebro University, Örebro, Sweden., Høivik ML; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway., Halfvarson J; Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden. jonas.halfvarson@regionorebrolan.se.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Jun 03; Vol. 15 (1), pp. 4567. Date of Electronic Publication: 2024 Jun 03.
DOI: 10.1038/s41467-024-48763-7
Abstrakt: Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-naïve pediatric patients and validating findings in an independent inception cohort. The lipidomic signature comprising of only lactosyl ceramide (d18:1/16:0) and phosphatidylcholine (18:0p/22:6) improves the diagnostic prediction compared with high-sensitivity C-reactive protein. Adding high-sensitivity C-reactive protein to the signature does not improve its performance. In patients providing a stool sample, the diagnostic performance of the lipidomic signature and fecal calprotectin, a marker of gastrointestinal inflammation, does not substantially differ. Upon investigation in a third pediatric cohort, the findings of increased lactosyl ceramide (d18:1/16:0) and decreased phosphatidylcholine (18:0p/22:6) absolute concentrations are confirmed. Translation of the lipidomic signature into a scalable diagnostic blood test for pediatric inflammatory bowel disease has the potential to support clinical decision making.
(© 2024. The Author(s).)
Databáze: MEDLINE
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