Study of endocrine disruptor effects in AVP and OT mediated behavioral and reproductive processes in female rat models.

Autor: Sepp K; Department of Internal Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary. Electronic address: sepp.krisztian@med.u-szeged.hu., László A; Department of Applied Statistics, Institute of Mathematics and Basic Science, Hungarian University of Agriculture and Life Sciences, Budapest, Hungary., Gálfi M; Institute of Applied Health Sciences and Environmental Education, Department of Environmental Biology and Education, Juhász Gyula Faculty of Education, University of Szeged, Szeged, Hungary., Radács M; Institute of Applied Health Sciences and Environmental Education, Department of Environmental Biology and Education, Juhász Gyula Faculty of Education, University of Szeged, Szeged, Hungary., Mózes M; Institute of Applied Health Sciences and Environmental Education, Department of Environmental Biology and Education, Juhász Gyula Faculty of Education, University of Szeged, Szeged, Hungary., Hausinger P; Department of Neurosurgery, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary., Pálföldi R; Department of Pulmonary Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Deszk, Hungary., Veszelka M; Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary., Valkusz Z; Department of Internal Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary., Molnár Z; Institute of Applied Health Sciences and Environmental Education, Department of Environmental Biology and Education, Juhász Gyula Faculty of Education, University of Szeged, Szeged, Hungary.
Jazyk: angličtina
Zdroj: Physiology & behavior [Physiol Behav] 2024 Sep 01; Vol. 283, pp. 114597. Date of Electronic Publication: 2024 Jun 02.
DOI: 10.1016/j.physbeh.2024.114597
Abstrakt: Environmental exposures may have endocrine disruptor (ED) effects, e.g., a role for halogenated hydrocarbon chlorobenzenes in increasing vasopressin (AVP), oxytocin (OT) secretion and, in association, anxiety and aggression in male rats has been shown. Our aim is to investigate whether 1,2,4-trichlorobenzenehexachlorobenzene= 1:1 (mClB) treatment of female rats also shows ED effects and reproductive biology differences, and whether AVP may have a mediator role in this? Female Wistar rats were treated (0.1; 1.0; 10.0 μg/bwkg/day) with mClB (by gastrictube) and then 30; 60; 90 days after treatment anxiety (open field test) and aggressive (resident intruder test) behaviors AVP, OT concentrations from blood plasma samples were detected by radioimmunoassay on 30; 60; 90 days. Treated female rats were mated with untreated males. Mating success, number of newborn and maternal aggression on the neonates were monitored. Results showed that AVP, OT levels; and anxiety, aggressive behaviors; and mothers' aggression towards their offspring increased significantly in relation to the duration and the dose of mClB treatment. But mating propensity and number of offspring decreased. Patterns of AVP, OT release and anxiety, aggression behaviors, and reproductive-related behaviors were correlated. Consistent with the literature, our studies confirmed the role of AVP and OT in different behavioral effects.
(Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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