| Autor: |
Haddaji A; Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.; Laboratory of virology, oncology, biosciences, environment and new energies, Faculty of Sciences and Techniques of Mohammedia, Hassan II University of Casablanca, Casablanca, Morocco., Ouladlahsen A; Faculté de médecine et de pharmacie, Université Hassan II, Casablanca, Morocco.; Service des maladies Infectieuses, CHU Ibn Rochd, Casablanca, Morocco., Lkhider M; Laboratory of virology, oncology, biosciences, environment and new energies, Faculty of Sciences and Techniques of Mohammedia, Hassan II University of Casablanca, Casablanca, Morocco., Tanouti IA; Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco., Abbadi I; Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco., Hilmi S; Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco., Bensghir R; Service des maladies Infectieuses, CHU Ibn Rochd, Casablanca, Morocco., Guessous F; Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.; Department of Microbiology, Immunology and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA, USA., Pineau P; Unité 'Organisation Nucléaire et Oncogenèse', INSERM U993, Institut Pasteur, Paris, France., Marhoum El Filali K; Faculté de médecine et de pharmacie, Université Hassan II, Casablanca, Morocco.; Service des maladies Infectieuses, CHU Ibn Rochd, Casablanca, Morocco., Ezzikouri S; Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco. |
| Abstrakt: |
Interleukin-6 (IL-6), a pro-inflammatory cytokine, is an important regulator of the inflammatory immune response. We aimed to assess the association of common single nucleotide polymorphisms (SNPs) in IL-6 (rs1800795 G > C, rs1800797 A > G) and interleukin-6 receptor ( IL-6R ) (rs2228145 A > C) genes with HIV-1 infection, AIDS progression, and response to treatment. In this case-control study involving 199 individuals living with HIV-1 and 200 HIV-uninfected controls, we conducted genotyping of IL-6/IL-6R SNPs using TaqMan real-time PCR assays. Soluble IL-6 levels were measured using ELISA. No associations were found between the investigated SNPs and HIV infection. However, a significant association was noted between the C-G and G-A haplotypes and susceptibility to HIV-1 infection. Additionally, a significant association was revealed between HIV-1 RNA viral loads and IL-6 SNP G > C in the post-treatment HIV group. Interestingly, we observed a significant association between the investigated SNPs and protection against progression to AIDS, namely the IL-6 G > A SNP in its recessive model and the IL-6R A > C SNP in its codominant and dominant models. Nevertheless, we found no significant differences between IL-6 levels and the different genotypes and alleles of the IL-6 gene either before or after combination antiretroviral therapy. IL-6 promoter haplotypes are associated with susceptibility to HIV-1 infection. Furthermore, IL-6 A > G and IL-6R A > C polymorphisms have been associated with protection against AIDS progression. Interestingly, the IL-6 G > C SNP may affect the response to treatment in people living with HIV-1. |
