Effectiveness of topical hyaluronic acid of different molecular weights in xerosis cutis treatment in elderly: a double-blind, randomized controlled trial.

Autor: Muhammad P; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia/dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia., Novianto E; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia/dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia. endinoviantodr@gmail.com., Setyorini M; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia/dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia., Legiawati L; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia/dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia., Yusharyahya SN; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia/dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia., Menaldi SL; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia/dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia., Budianti WK; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia/dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia.
Jazyk: angličtina
Zdroj: Archives of dermatological research [Arch Dermatol Res] 2024 Jun 03; Vol. 316 (6), pp. 329. Date of Electronic Publication: 2024 Jun 03.
DOI: 10.1007/s00403-024-03003-2
Abstrakt: Dry skin is a common dermatological condition that frequently affects the elderly. A contributing cause to dry skin is a reduced concentration of hyaluronic acid (HA) in both the epidermis and dermis. The effectiveness of moisturizer containing HA as a therapy for dry skin is impacted by its specific molecular weight. Low molecular weight HA (LMWHA) is believed to be more effective in replenishing skin hydration in aging skin compared to High Molecular Weight HA (HMWHA) due to its ability to penetrate the stratum corneum. However, there is a lack of clinical research supporting this claim. A double-blind, randomized controlled trial was conducted on 36 residents of a nursing home in Jakarta. The participants, aged between 60 and 80 years, had been diagnosed with dry skin. Each test subject was administered three distinct, randomized moisturizing lotions (LMWHA, HMWHA, or vehicle), to be topically applied to three separate sites on the leg. Skin capacitance (SCap), transepidermal water loss (TEWL), and specified symptom sum score (SRRC) were measured at weeks 0, 2, and 4. After four weeks of therapy, area that was treated with LMWHA showed greater SCap values compared to the area treated with HMWHA (56.37 AU vs. 52.37 AU, p = 0.004) and vehicle (56.37 AU vs. 49.01 AU, p < 0.001). All groups did not show any significant differences in TEWL and SRRC scores. No side effects were found in all groups. The application of a moisturizer containing LMWHA to the dry skin of elderly resulted in significant improvements in skin hydration compared to moisturizers containing HMWHA and vehicle. Furthermore, these moisturizers demonstrated similar safety in treating dry skin in the elderly. ClinicalTrials.gov Identifier NCT06178367, https://clinicaltrials.gov/study/NCT06178367 .
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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