High variance in quantification of Mycobacterium tuberculosis at low bacterial loads and with differentially detectable mycobacteria.

Autor: Walsh KF; Center for Global Health, Weill Cornell Medicine, New York, New York, USA.; Division of General Internal Medicine, Department of Medicine, Weill Cornell Medicine, New York, New York, USA., Lee MH; Center for Global Health, Weill Cornell Medicine, New York, New York, USA., Zainabadi K; Center for Global Health, Weill Cornell Medicine, New York, New York, USA., Vilbrun SC; Department of Medicine, Groupe Haïtien d'Étude du Sarcome de Kaposi et des Infectieuses Opportunistes (GHESKIO), Port-au-Prince, Haiti., Jean Juste MA; Department of Medicine, Groupe Haïtien d'Étude du Sarcome de Kaposi et des Infectieuses Opportunistes (GHESKIO), Port-au-Prince, Haiti., Joseph Y; Department of Medicine, Groupe Haïtien d'Étude du Sarcome de Kaposi et des Infectieuses Opportunistes (GHESKIO), Port-au-Prince, Haiti., Royal G; Department of Medicine, Groupe Haïtien d'Étude du Sarcome de Kaposi et des Infectieuses Opportunistes (GHESKIO), Port-au-Prince, Haiti., Saito K; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, New York, USA., McAulay K; Center for Global Health, Weill Cornell Medicine, New York, New York, USA., Pape JW; Center for Global Health, Weill Cornell Medicine, New York, New York, USA.; Department of Medicine, Groupe Haïtien d'Étude du Sarcome de Kaposi et des Infectieuses Opportunistes (GHESKIO), Port-au-Prince, Haiti., Fitzgerald D; Center for Global Health, Weill Cornell Medicine, New York, New York, USA.
Jazyk: angličtina
Zdroj: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Jul 09; Vol. 68 (7), pp. e0160123. Date of Electronic Publication: 2024 Jun 03.
DOI: 10.1128/aac.01601-23
Abstrakt: We examined the correlation between three different methods of Mycobacterium tuberculosis quantification: time to positivity (TTP), log 10 CFU, and an assay to detect differentially detectable M. tuberculosis (DD Mtb) from three different prospective studies. Participants with DD Mtb have significantly more variation in the CFU/TTP correlation than participants with no DD Mtb ( P < 0.001). This may impact the design of early bactericidal activity studies that use TTP as the primary outcome.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
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