Aqueous Graphene Dispersion and Biofunctionalization via Enzymatic Oxidation of Tripeptides.

Autor: Barriales K; Advanced Science Research Center (ASRC) at the Graduate Center, City University of New York (CUNY), 85 St Nicholas Terrace, New York, NY, 10031, USA.; Department of Chemistry, Hunter College, City University of New York, 695 Park Avenue, New York, NY, 10065, USA.; Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, NY, 10016, USA., Khandaker S; Advanced Science Research Center (ASRC) at the Graduate Center, City University of New York (CUNY), 85 St Nicholas Terrace, New York, NY, 10031, USA., Jain A; Advanced Science Research Center (ASRC) at the Graduate Center, City University of New York (CUNY), 85 St Nicholas Terrace, New York, NY, 10031, USA.; Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, NY, 10016, USA.; Department of Chemistry and biochemistry, Brooklyn College, City University of New York, 2900 Bedford Avenue, Brooklyn, NY, 11210, USA., Sementa D; Advanced Science Research Center (ASRC) at the Graduate Center, City University of New York (CUNY), 85 St Nicholas Terrace, New York, NY, 10031, USA., Nair MN; Advanced Science Research Center (ASRC) at the Graduate Center, City University of New York (CUNY), 85 St Nicholas Terrace, New York, NY, 10031, USA., Wang T; Advanced Science Research Center (ASRC) at the Graduate Center, City University of New York (CUNY), 85 St Nicholas Terrace, New York, NY, 10031, USA., Tang J; Department of Chemistry, New York University, 32 Waverly Pl, New York, NY, 10003, USA., DelRe C; Advanced Science Research Center (ASRC) at the Graduate Center, City University of New York (CUNY), 85 St Nicholas Terrace, New York, NY, 10031, USA.; Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, NY, 10016, USA.; Department of Chemistry, The City College of New York, 160 Convent Avenue, New York, NY, 10031, USA., Ulijn RV; Advanced Science Research Center (ASRC) at the Graduate Center, City University of New York (CUNY), 85 St Nicholas Terrace, New York, NY, 10031, USA.; Department of Chemistry, Hunter College, City University of New York, 695 Park Avenue, New York, NY, 10065, USA.; Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, NY, 10016, USA.
Jazyk: angličtina
Zdroj: Small (Weinheim an der Bergstrasse, Germany) [Small] 2024 Sep; Vol. 20 (38), pp. e2400775. Date of Electronic Publication: 2024 Jun 03.
DOI: 10.1002/smll.202400775
Abstrakt: Graphene, a 2D carbon material, possesses extraordinary mechanical, electrical, and thermal properties, making it highly attractive for various biological applications such as biosensing, biotherapeutics, and tissue engineering. However, the tendency of graphene sheets to aggregate and restack hinders its dispersion in water, limiting these applications. Peptides, with their defined amino acid sequences and versatile functionalities, are compelling molecules with which to modify graphene-aromatic amino acids can strengthen interactions through π-stacking and charged groups can be chosen to make the sheets dispersible and stable in water. Here, a facile and green method for covalently functionalizing and dispersing graphene using amphiphilic tripeptides, facilitated by a tyrosine phenol side chain, through an aqueous enzymatic oxidation process is demonstrated. The presence of a second aromatic side chain group enhances this interaction through non-covalent support via π-π stacking with the graphene surface. Futhermore, the addition of charged moieties originating from either ionizable amino acids or terminal groups facilitates profound interactions with water, resulting in the dispersion of the newly functionalized graphene in aqueous solutions. This biofunctionalization method resulted in ≈56% peptide loading on the graphene surface, leading to graphene dispersions that remain stable for months in aqueous solutions outperforming currently used surfactants.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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