A Systematic Review Supporting the Endocrine Society Clinical Practice Guidelines on Vitamin D.

Autor:	Shah VP; Mayo Clinic Evidence-Based Practice Center, Rochester, MN 55905, USA., Nayfeh T; Mayo Clinic Evidence-Based Practice Center, Rochester, MN 55905, USA., Alsawaf Y; Mayo Clinic Evidence-Based Practice Center, Rochester, MN 55905, USA., Saadi S; Mayo Clinic Evidence-Based Practice Center, Rochester, MN 55905, USA., Farah M; Mayo Clinic Evidence-Based Practice Center, Rochester, MN 55905, USA., Zhu Y; Mayo Clinic Evidence-Based Practice Center, Rochester, MN 55905, USA., Firwana M; Mayo Clinic Evidence-Based Practice Center, Rochester, MN 55905, USA., Seisa M; Mayo Clinic Evidence-Based Practice Center, Rochester, MN 55905, USA., Wang Z; Mayo Clinic Evidence-Based Practice Center, Rochester, MN 55905, USA., Scragg R; School of Population Health, University of Auckland, Auckland 1023, New Zealand., Kiely ME; Cork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences and INFANT Research Centre, University College Cork, Cork T12 Y337, Ireland., Lips P; Internal Medicine, Endocrine Section, Amsterdam University Medical Center, Amsterdam 1007 MB, The Netherlands., Mitchell DM; Pediatric Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Demay MB; Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Pittas AG; Divisions of Endocrinology, Diabetes and Metabolism, Tufts-New England Medical Center, Boston, MA 02116, USA., Murad MH; Mayo Clinic Evidence-Based Practice Center, Rochester, MN 55905, USA.
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2024 Jul 12; Vol. 109 (8), pp. 1961-1974.
DOI:	10.1210/clinem/dgae312
Abstrakt:	Context: Low vitamin D status is common and is associated with various common medical conditions. Objective: To support the development of the Endocrine Society's Clinical Practice Guideline on Vitamin D for the Prevention of Disease. Methods: We searched multiple databases for studies that addressed 14 clinical questions prioritized by the guideline panel. Of the 14 questions, 10 clinical questions assessed the effect of vitamin D vs no vitamin D in the general population throughout the lifespan, during pregnancy, and in adults with prediabetes; 1 question assessed dosing; and 3 questions addressed screening with serum 25-hydroxyvitamin D (25[OH]D). The Grading of Recommendations Assessment, Development and Evaluation approach was used to assess certainty of evidence. Results: Electronic searches yielded 37 007 citations, from which we included 151 studies. In children and adolescents, low-certainty evidence suggested reduction in respiratory tract infections with empiric vitamin D. There was no significant effect on select outcomes in healthy adults aged 19 to 74 years with variable certainty of evidence. There was a very small reduction in mortality among adults older than 75 years with high certainty of evidence. In pregnant women, low-certainty evidence suggested possible benefit on various maternal, fetal, and neonatal outcomes. In adults with prediabetes, moderate certainty of evidence suggested reduction in the rate of progression to diabetes. Administration of high-dose intermittent vitamin D may increase falls, compared to lower-dose daily dosing. We did not identify trials on the benefits and harms of screening with serum 25(OH)D. Conclusion: The evidence summarized in this systematic review addresses the benefits and harms of vitamin D for the prevention of disease. The guideline panel considered additional information about individuals' and providers' values and preferences and other important decisional and contextual factors to develop clinical recommendations. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com. See the journal About page for additional terms.)
Databáze:	MEDLINE
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