Five New Furostanol Glycosides from the Fruits of Tribulus terrestris with NO Production Inhibitory Activity.

Autor: Kiem PV; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam., Quoc NV; School of Chemistry, Biology and Environment, Vinh University, 182 Le Duan, Ben Thuy, Vinh City, Nghe An, 461010, Vietnam., Tai BH; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam., Yen PH; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam., Huy Hoang N; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam., Thi Thuy Hang D; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam., Huong PTT; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam., Anh Bang N; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam., Dung DT; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam., Trang DT; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam., Giang LD; Department of Chemistry, Vinh University, 182 Le Duan, Ben Thuy, Vinh City, Nghe An, 461010, Vietnam.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Sep; Vol. 21 (9), pp. e202401273. Date of Electronic Publication: 2024 Jul 16.
DOI: 10.1002/cbdv.202401273
Abstrakt: Eight furostanol glycosides including five undescribed compounds, named tribufurostanosides A-E (1-5), and three known ones (6-8) were isolated from the fruits of Tribulus terrestris L. Their chemical structures were determined by the IR, HR-ESI-MS, 1D-, and 2D-NMR spectra. Furostanols 1-8 significantly inhibited nitric oxide production in LPS activated RAW 264.7 cells with IC 50 values ranging from 14.2 to 64.7 μM, compared to that of the positive control compound, dexamethazone (IC 50 13.6 μM).
(© 2024 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE