Effects of extracellular vesicles for ischemic stroke: A meta‑analysis of preclinical studies.

Autor: Xie Y; Department of Neurology, The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine, Changsha, Hunan 410000, P.R. China., Deng T; Department of Oncology, The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine, Changsha, Hunan 410000, P.R. China., Xie L; Department of Neurology, The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine, Changsha, Hunan 410000, P.R. China., Xie Y; Department of Neurology, The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine, Changsha, Hunan 410000, P.R. China., Ma J; Department of Neurology, The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine, Changsha, Hunan 410000, P.R. China., Zhong D; Department of Neurology, The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine, Changsha, Hunan 410000, P.R. China., Huang X; Department of Neurology, The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine, Changsha, Hunan 410000, P.R. China., Li Y; Department of Neurology, The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine, Changsha, Hunan 410000, P.R. China.
Jazyk: angličtina
Zdroj: Experimental and therapeutic medicine [Exp Ther Med] 2024 May 16; Vol. 28 (1), pp. 287. Date of Electronic Publication: 2024 May 16 (Print Publication: 2024).
DOI: 10.3892/etm.2024.12575
Abstrakt: Ischemic stroke is a common occurrence worldwide, posing a severe threat to human health and leading to negative financial impacts. Currently available treatments still have numerous limitations. As research progresses, extracellular vesicles are being found to have therapeutic potential in ischemic stroke. In the present study, the literature on extracellular vesicle therapy in animal studies of ischemic stroke was screened by searching databases, including PubMed, Embase, Medline, Web of Science and the Cochrane Library. The main outcomes of the present study were the neurological function score, apoptotic rate and infarct volumes. The secondary outcomes were pro-inflammatory factors, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-6. The study quality was assessed using the CAMARADES Checklist. Subgroup analyses were performed to evaluate factors influencing extracellular vesicle therapy. Review Man3ager5.3 was used for data analysis. A total of 20 relevant articles were included in the present meta-analysis. The comprehensive analysis revealed that extracellular vesicles exerted a significant beneficial effect on neurobehavioral function, reducing the infarct volume and decreasing the apoptotic rate. Moreover, extracellular vesicles were found to promote nerve recovery by inhibiting pro-inflammatory factors (TNF-α, IL-1β and IL-6). On the whole, the present meta-analysis examined the combined effects of extracellular vesicles on nerve function, infarct volume, apoptosis and inflammation, which provides a foundation for the clinical study of extracellular vesicles.
Competing Interests: The authors declare that they have no competing interests.
(Copyright: © 2024 Xie et al.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje