Effects of mid‑gestational sevoflurane and magnesium sulfate on maternal oxidative stress, inflammation and fetal brain histopathology.

Autor: Ozdemi R C; Department of Anesthesiology and Reanimation, Mamak State Hospital, 06270 Ankara, Turkey., Isik B; Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, 06560 Ankara, Turkey., Koca G; Department of Medical Biochemistry, Faculty of Medicine, Gazi University, 06560 Ankara, Turkey., Inan MA; Department of Medical Pathology, Faculty of Medicine, Gazi University, 06560 Ankara, Turkey.
Jazyk: angličtina
Zdroj: Experimental and therapeutic medicine [Exp Ther Med] 2024 May 16; Vol. 28 (1), pp. 286. Date of Electronic Publication: 2024 May 16 (Print Publication: 2024).
DOI: 10.3892/etm.2024.12574
Abstrakt: Models of inflammation, oxidative stress, hyperoxia and hypoxia have demonstrated that magnesium sulfate (MgSO 4 ), a commonly used drug in obstetrics, has neuroprotective potential. In the present study, the effects of MgSO 4 treatment on inflammation, oxidative stress and fetal brain histopathology were evaluated in an experimental rat model following sevoflurane (Sv) exposure during the mid-gestational period. Rats were randomly divided into groups: C (control; no injections or anesthesia), Sv (exposure to 2.5% Sv for 2 h), MgSO 4 (administered 270 mg/kg MgSO 4 intraperitoneally) and Sv + MgSO 4 (Sv administered 30 min after MgSO 4 injection). Inflammatory and oxidative stress markers were measured in the serum and neurotoxicity was investigated histopathologically in fetal brain tissue. Short-term mid-gestational exposure to a 1.1 minimum alveolar concentration of Sv did not significantly increase the levels of any of the measured biochemical markers, except for TNF-α. Histopathological evaluations demonstrated no findings suggestive of pathological apoptosis, neuroinflammation or oxidative stress-induced cell damage. MgSO 4 injection prior to anesthesia caused no significant differences in biochemical or histopathological marker levels compared to the C and Sv groups. The present study indicated that short-term exposure to Sv could potentially be considered a harmless external stimulus to the fetal brain.
Competing Interests: The authors declare that they have no competing interests.
(Copyright: © 2024 Ozdemi̇r et al.)
Databáze: MEDLINE
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