| Autor: |
Singha T; Laboratoire Physique des Cellules et Cancer (PCC), Institut Curie, PSL Research University, CNRS UMR168, 75005 Paris, France., Li SF; Department of Physics, University of Massachusetts, Amherst, Massachusetts 01003, USA., Muthukumar M; Department of Polymer Science and Engineering, University of Massachusetts, Amherst, Massachusetts 01003, USA. |
| Abstrakt: |
We study the role of active coupling on the transport properties of homogeneously charged macromolecules in an infinitely dilute solution. An enzyme becomes actively bound to a segment of the macromolecule, exerting an electrostatic force on it. Eventually, thermal fluctuations cause it to become unbound, introducing active coupling into the system. We study the mean-squared displacement (MSD) and find a new scaling regime compared to the thermal counterpart in the presence of hydrodynamic and segment-segment electrostatic interactions. Furthermore, the study of segment-segment equal-time correlation reveals the swelling of the macromolecule. Further, we derive the concentration equation of the macromolecule with active binding and study how the cooperative diffusivity of the macromolecules get modified by its environment, including the macromolecules itself. It turns out that these active fluctuations enhance the effective diffusivity of the macromolecules. The derived closed-form expression for diffusion constant is pertinent to the accurate interpretation of light scattering data in multi-component systems with binding-unbinding equilibria. |
