Circulating microaggregates as biomarkers for the Post-COVID syndrome.
| Autor: | Hermann M; Department of Anesthesia and Intensive Care, Medical University Innsbruck, Austria., Lisch C; Sanatorium Hochrum, Rum, Austria., Gerth R; Specialized Laboratories Wick, Speckbacherstrasse 23, A-6020 Innsbruck, Austria., Wick G; Division of Pathophysiology, Biocenter, Innsbruck Medical University, Austria., Fries D; Division of Pathophysiology, Biocenter, Innsbruck Medical University, Austria., Wick N; Specialized Laboratories Wick, Speckbacherstrasse 23, A-6020 Innsbruck, Austria. |
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| Jazyk: | angličtina |
| Zdroj: | IDCases [IDCases] 2024 May 24; Vol. 36, pp. e02000. Date of Electronic Publication: 2024 May 24 (Print Publication: 2024). |
| DOI: | 10.1016/j.idcr.2024.e02000 |
| Abstrakt: | CoVID-19 can develop into Post-COVID syndrome of potentially high morbidity, with procoagulation and reactivation of dormant viral infections being hypothesized pathophysiological mechanisms. We report on a patient suffering from fatigue, post exertional malaise, pain and neurological symptoms as a consequence of the second CoVID infection. Using live confocal microscopy on native whole blood samples we detected microaggregates of thrombocytes, leukocytes and plasma proteins in peripheral blood. In addition, there was specific cellular immunological reactivity to EBV. Upon anticoagulatory and virustatic pharmacological therapy we observed dissolution of microaggregates and significant stable clinical remission. We suggest to consider circulating microaggregates as a morphological indicator of chronic post-COVID syndrome. Competing Interests: We declare no competing interests. (© 2024 The Authors.) |
| Databáze: | MEDLINE |
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